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FN18-CRM9

National Institutes of Health

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3 relations

Broader (3)

Diphtheria ToxinMonoclonal AntibodiesRecombinant Fusion Proteins

Papers overview

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2012
2012
Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment.
2008
2008
Retraction: Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.
BACKGROUND Tolerance is gaining momentum as an approach to reduce lifelong immunosuppressive therapy while improving transplant… 
2001
2001
IMMUNOTOXIN FN18-CRM9 INDUCES STRONGER T CELL SIGNALING THAN UNCONJUGATED MONOCLONAL ANTIBODY FN1812
Background. The T-cell receptor (TCR)/CD3 complex is the target of therapeutic strategies aimed at prolonging allograft survival… 
2000
2000
Increased glomerular deposits of von Willebrand factor in chronic, but not acute, rejection of primate renal allografts.
BACKGROUND In our previously described primate renal allograft model, T cell ablation leads to long-term graft survival. The role… 
2000
2000
SKIN ALLOGRAFT ACCEPTANCE IN LONG‐SURVIVING NONHUMAN PRIMATE RENAL ALLOGRAFT RECIPIENTS TREATED WITH FN18‐CRM9.: Abstract# 501 Poster Board #‐Session: P141‐II
1999
1999
Activation of T lymphocytes for adhesion and cytokine expression by toxin-conjugated anti-CD3 monoclonal antibodies.
BACKGROUND Immunosuppressive drugs that target T cells are useful for prolonging allograft survival. The anti-CD3 immunotoxin… 
Highly Cited
1998
Highly Cited
1998
Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9.
BACKGROUND FN18-CRM9 is a CD3-specific immunotoxin that is capable of depleting CD3+ T cells. Pretreatment of rhesus monkeys with… 
Highly Cited
1997
Highly Cited
1997
Split tolerance induced by immunotoxin in a rhesus kidney allograft model.
BACKGROUND Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells… 
1997
1997
Genetic construction and characterization of an anti-monkey CD3 single-chain immunotoxin with a truncated diphtheria toxin.
We have previously developed a chemically conjugated anti-rhesus monkey CD3 immunotoxin FN18-CRM9 that can deplete in vivo T… 
1997
1997
Depletion of T lymphocytes with immunotoxin retards the progress of experimental allergic encephalomyelitis in rhesus monkeys.
FN18-CRM9 is an anti-rhesus anti-CD3 immunotoxin that can transiently deplete T cells to 1% of initial values in both the blood… 
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