FLNA protein, human

Known as: filamin A, alpha (actin binding protein 280), human, EC 6.3.4.4, Actin Binding Protein 280 
Filamin-A (2647 aa, ~281 kDa) is encoded by the human FLNA gene. This protein is involved in cytoskeletal remodeling.
National Institutes of Health

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4 relations
FLNA geneStructural gene

Broader (2)

Filamin AFilamins

Papers overview

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Review
2013
Review
2013
The calcium sensing receptor life cycle: trafficking, cell surface expression, and degradation.
The calcium-sensing receptor (CaSR) must function in the chronic presence of agonist, and recent studies suggest that its ability… (More)
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2010
2010
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying… (More)
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2010
2010
Protein analysis of purified respiratory syncytial virus particles reveals an important role for heat shock protein 90 in virus particle assembly.
In this study, we used imaging and proteomics to identify the presence of virus-associated cellular proteins that may play a role… (More)
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Highly Cited
2006
Highly Cited
2006
Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Mutations in the human Filamin A (FLNA) gene disrupt neuronal migration to the cerebral cortex and cause cardiovascular defects… (More)
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Highly Cited
2006
Highly Cited
2006
Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle.
Skeletal muscle contraction stimulates multiple signaling cascades that govern a variety of metabolic and transcriptional events… (More)
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Highly Cited
2006
Highly Cited
2006
Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.
The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally upregulated in the vasculature of solid… (More)
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Highly Cited
2006
Highly Cited
2006
Cardiac malformations and midline skeletal defects in mice lacking filamin A.
The X-linked gene filamin A (Flna) encodes a widely expressed actin-binding protein that crosslinks actin into orthogonal… (More)
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Highly Cited
2006
Highly Cited
2006
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
FilGAP is a newly recognized filamin A (FLNa)-binding RhoGTPase-activating protein. The GTPase-activating protein (GAP) activity… (More)
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2005
2005
The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.
Myotilin and the calsarcin family member FATZ-1 (also called calsarcin-2 or myozenin-1) are recently discovered sarcomeric… (More)
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Highly Cited
2002
Highly Cited
2002
A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg…
Although proteins phosphorylated on tyrosine residues can be enriched by immunoprecipitation with anti-phosphotyrosine antibodies… (More)
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