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FLNA protein, human

Known as: filamin A, alpha (actin binding protein 280), human, EC 6.3.4.4, Actin Binding Protein 280 
Filamin-A (2647 aa, ~281 kDa) is encoded by the human FLNA gene. This protein is involved in cytoskeletal remodeling.
National Institutes of Health

Related topics

Related topics

4 relations
FLNA geneStructural gene

Broader (2)

Filamin AFilamins

Papers overview

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Highly Cited
2007
Highly Cited
2007
Structural basis of filamin A functions
Filamin A (FLNa) can effect orthogonal branching of F-actin and bind many cellular constituents. FLNa dimeric subunits have N… Expand
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Highly Cited
2006
Highly Cited
2006
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
FilGAP is a newly recognized filamin A (FLNa)-binding RhoGTPase-activating protein. The GTPase-activating protein (GAP) activity… Expand
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Highly Cited
2006
Highly Cited
2006
Filamin A (FLNA) is required for cell–cell contact in vascular development and cardiac morphogenesis
Mutations in the human Filamin A (FLNA) gene disrupt neuronal migration to the cerebral cortex and cause cardiovascular defects… Expand
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Highly Cited
2006
Highly Cited
2006
The structure of the GPIb-filamin A complex.
Filamin A (FLNa), a dimeric actin cross-linking and scaffold protein with numerous intracellular binding partners, anchors the… Expand
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Highly Cited
2003
Highly Cited
2003
Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions
The androgen receptor (AR), a nuclear transcription factor, mediates male sexual differentiation, and its excessive action is… Expand
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Highly Cited
2002
Highly Cited
2002
A Mass Spectrometry-based Proteomic Approach for Identification of Serine/Threonine-phosphorylated Proteins by Enrichment with Phospho-specific Antibodies
Although proteins phosphorylated on tyrosine residues can be enriched by immunoprecipitation with anti-phosphotyrosine antibodies… Expand
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Highly Cited
2002
Highly Cited
2002
Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome.
An absent platelet glycoprotein (GP) Ib-IX receptor results in the Bernard-Soulier syndrome and is characterized by severe… Expand
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Highly Cited
2001
Highly Cited
2001
Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A
We have used a yeast two-hybrid approach to uncover protein interactions involving the D2-like subfamily of dopamine receptors… Expand
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Highly Cited
2001
Highly Cited
2001
Mechanical unfolding of single filamin A (ABP‐280) molecules detected by atomic force microscopy
Filamin A (ABP‐280), which is an actin‐binding protein of 560 kDa as a dimer, can, together with actin filaments, produce an… Expand
Highly Cited
2000
Highly Cited
2000
Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280).
Proteins that bind to G protein-coupled receptors have recently been identified as regulators of receptor anchoring and signaling… Expand
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