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International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of Pharmacology subcommittee. More receptor…
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.
P2 receptors: intracellular signaling
Intracellular signaling cascades are the main routes of communication between G-protein-coupled receptors and regulatory targets within the cell and there are numerous ion channels, cell adhesion molecules and receptor tyrosine kinases that operate to transmit an extracellular signal to an intracellular response.
Src Homology 3 Binding Sites in the P2Y2 Nucleotide Receptor Interact with Src and Regulate Activities of Src, Proline-rich Tyrosine Kinase 2, and Growth Factor Receptors*
Dual immunofluorescence labeling of the P2Y2 receptor and the EGFR indicated that UTP caused an increase in the co-localization of these receptors in the plasma membrane that was prevented by the Src inhibitor PP2.
Coupling of P2Y receptors to G proteins and other signaling pathways.
P2Y receptors are G protein-coupled receptors that are activated by adenine and uridine nucleotides and nucleotide sugars, which activate intracellular signaling cascades to regulate a variety of cellular processes, including proliferation, differentiation, phagocytosis, secretion, nociception, cell adhesion, and cell migration.
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.
- C. E. Parr, D. Sullivan, J. T. Turner
- BiologyProceedings of the National Academy of Sciences…
- 12 April 1994
expression of the human P2U receptor (HP2U) in 1321N1 cells revealed evidence for autocrine ATP release and stimulation of transduced receptors, which will be useful for studying autocrine regulatory mechanisms and in screening of potential therapeutic drugs.
Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet.
- J. Dixon, J. D. Stoops, J. L. Parker, M. Laughlin, G. Weisman, M. Sturek
- Medicine, BiologyArteriosclerosis, thrombosis, and vascular…
- 1 December 1999
This porcine model of pigs made diabetic by destroying the insulin-producing cells of the pancreas with alloxan and then fed a high fat and high cholesterol diet should provide insights into the etiology of human diabetic dyslipidemia and facilitate study of peripheral vascular and coronary artery disease in diabetic patients.
Neuroprotective mechanisms of curcumin against cerebral ischemia‐induced neuronal apoptosis and behavioral deficits
The neuroprotective effect of curcumin is attributed against I/R‐induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death.
An Rgd Sequence in the P2y2 Receptor Interacts with αVβ3 Integrins and Is Required for Go-Mediated Signal Transduction
Interactions between P2Y2Rs, integrins, and CD47 may be important for coupling the P1Y2R to Go, but not Gq.
The P2Y2 Nucleotide Receptor Mediates Vascular Cell Adhesion Molecule-1 Expression through Interaction with VEGF Receptor-2 (KDR/Flk-1)*
- C. Seye, N. Yu, F. González, L. Erb, G. Weisman
- BiologyJournal of Biological Chemistry
- 20 August 2004
Activation of the P2Y2R induced rapid tyrosine phosphorylation of vascular endothelial growth factor receptor (VEGFR)-2 in human coronary artery endothelial cells (HCAEC) and this data indicate a novel mechanism whereby a nucleotide receptor transactivates a receptor tyosine kinase to generate an inflammatory response associated with atherosclerosis.