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FLCN gene

Known as: Folliculin Gene, FLCN, FOLLICULIN 
This gene may play a role in tumor suppression.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Proliferation Regulatory ProcessFLCN protein, humanHomo sapiensMultiple fibrofolliculomas

Narrower (1)

FLCN wt Allele

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling
C9orf72 interacts strongly with SMCR8 and depends on this interaction for its stability. Lysosomes are major sites of C9orf72… 
Highly Cited
2015
Highly Cited
2015
High-volume online haemodiafiltration improves erythropoiesis-stimulating agent (ESA) resistance in comparison with low-flux bicarbonate dialysis: results of the REDERT study.
BACKGROUND In haemodialysis (HD) patients, anaemia is associated with reduced survival. Despite treatment with erythropoiesis… 
Highly Cited
2013
Highly Cited
2013
Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3
Highly Cited
2012
Highly Cited
2012
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN.
BACKGROUND Birt-Hogg-Dubé (BHD) syndrome is a hereditary hamartoma syndrome that predisposes patients to develop hair follicle… 
Highly Cited
2011
Highly Cited
2011
Renal cancer and pneumothorax risk in Birt–Hogg–Dubé syndrome; an analysis of 115 FLCN mutation carriers from 35 BHD families
Background:Birt–Hogg–Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised… 
Highly Cited
2010
Highly Cited
2010
A new locus‐specific database (LSDB) for mutations in the folliculin (FLCN) gene
Birt‐Hogg‐Dubé syndrome (BHD) is an autosomal dominant condition characterised by the presence of facial fibrofolliculomas… 
Highly Cited
2008
Highly Cited
2008
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.
BACKGROUND Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in the BHD tumor suppressor gene that are… 
Highly Cited
2008
Highly Cited
2008
Identification and characterization of a novel folliculin-interacting protein FNIP2.
Review
2004
Review
2004
Searching for the hereditary causes of renal-cell carcinoma
Families with hereditary predispositions to cancer continue to provide a unique opportunity for the identification and… 
Highly Cited
2002
Highly Cited
2002
Clinical and genetic studies of Birt-Hogg-Dubé syndrome
Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominant cancer syndrome characterised by benign skin tumours, renal tumours, and… 
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