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Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre‐mediated excision
Summary: The Cre/loxP system has become an important tool in designing postintegrational switch mechanisms for transgenes in mice. The power and spectrum of application of this system depends onExpand
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Microsatellite allelotyping differentiates chromophobe renal cell carcinomas from renal oncocytomas and identifies new genetic changes
Aims:  The diagnosis of renal oncocytomas (ROs) and chromophobe renal cell carcinomas (RCCs) based on histological features is often uncertain. To assess the value of genetic analysis in theirExpand
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Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease.
Renal cell carcinoma occurs at higher frequency in acquired cystic renal disease than in the general population. We have analyzed 4 tumors obtained from the kidneys of 2 patients with acquired cysticExpand
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Somatic mitochondrial DNA mutations in human chromophobe renal cell carcinomas
We sequenced the entire mitochondrial genome in 8 chromophobe renal cell carcinomas (RCCs) and corresponding normal kidneys. Our study disclosed 68 known and 45 new sequence variations occurring 132Expand
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Mutations of mtDNA in renal cell tumours arising in end‐stage renal disease
Toxic effects in the uraemic state or during maintenance dialysis have been suggested to be responsible for DNA damage and tumour development in end‐stage renal disease (ESRD). This study thereforeExpand
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Accumulation of Allelic Changes at Chromosomes 7p, 18q, and 2 in Parathyroid Lesions of Uremic Patients
We examined by microsatellite allelotyping 69 hyperplastic lesions of the parathyroid glands from 23 patients with refractory, uremic hyperparathyroidism. Allelic changes, at least at one chromosomalExpand
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Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3.
DNA alterations at chromosome 5q22 occur frequently in different types of tumors including urological cancers. Previously, we narrowed a common target region between loci D5S659 and D5S2055 atExpand
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Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients.
Pancreatic cancer is on the increase. While means of early diagnosis are being sought, it continues to present late. Prognostication is based on patient and tumor characteristics, includingExpand
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Phosphatemia is related to chromosomal aberrations of parathyroid glands in patients with hyperparathyroidism.
BACKGROUND AND AIMS It has been well documented that gene and DNA alterations occur frequently in benign primary parathyroid adenomas as well as in parathyroid glands with secondary hyperplasia.Expand
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Molecular analysis of germline t(3;6) and t(3;12) associated with conventional renal cell carcinomas indicates their rate-limiting role and supports the three-hit model of carcinogenesis.
We describe the molecular analysis of chromosomal rearrangements in familial t(3;6)(p12.3;q24.3) and t(3;12)(q13.13;q24.23) associated with the development of conventional renal cell carcinomasExpand
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