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FKBP5 wt Allele

Known as: P54, FKBP51, Ptg-10 
Human FKBP5 wild-type allele is located in the vicinity of 6p21.31 and is approximately 155 kb in length. This allele, which encodes peptidyl-prolyl… 
National Institutes of Health

Related topics

Related topics

5 relations
6p21.31Receptor SignalingSignal Transductionprotein folding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States.
The recently discovered SAFit class of inhibitors against the Hsp90 co-chaperone FKBP51 show greater than 10 000-fold selectivity… 
2019
2019
A novel decalin-based bicyclic scaffold for FKBP51-selective ligands.
Selective inhibition of FKBP51 has emerged as possible novel treatment for diseases like major depressive disorder, obesity… 
Highly Cited
2015
Highly Cited
2015
FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma
Melanoma is the most aggressive skin cancer; its prognosis, particularly in advanced stages, is disappointing largely due to the… 
Review
2015
Review
2015
FKBPs and their role in neuronal signaling.
Review
2015
Review
2015
Recent Progress in FKBP Ligand Development.
FK506-binding proteins have been implicated in numerous human diseases suggesting novel therapeutic opportunities. In particular… 
2015
2015
Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins*
Background: FK506-binding protein 51 (FKBP51) inhibits and FKBP52 stimulates transcription by various steroid receptors. Exchange… 
2013
2013
Prenatal Alcohol Exposure Is Associated with Altered Subcellular Distribution of Glucocorticoid and Mineralocorticoid Receptors in the Adolescent Mouse Hippocampal Formation
Background Accumulating evidence indicates that several of the long-term consequences of prenatal alcohol exposure (PAE) are the… 
Highly Cited
2008
Highly Cited
2008
FK506-Binding Protein 51 Regulates Nuclear Transport of the Glucocorticoid Receptor (cid:1) and Glucocorticoid Responsiveness
P . A spliced variant of the human glucocorticoid recep- tor GR (cid:1) has been implicated in glucocorticoid responsiveness in… 
2008
2008
FKBP51 Expressed by Both Normal Epithelial Cells and Adenocarcinoma of Colon Suppresses Proliferation of Colorectal Adenocarcinoma
It has been reported, as a result of Western blot analyses, that FKBP51 is expressed in various tissues, but that it is not… 
Highly Cited
1995
Highly Cited
1995
Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation.
Mouse 3T3-L1 cells differentiate into fat-laden adipocytes in response to a cocktail of adipogenic hormones. This conversion… 
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