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FK 973

Known as: FK-973, FK973 
National Institutes of Health

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Oxazines

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Highly Cited
2004
Highly Cited
2004
In vitro antitumor activity of mitomycin C derivative (RM-49) and new anticancer antibiotics (FK973) against lung cancer cell lines determined by tetrazolium dye (MTT) assay
SummarySeven small- (SCLC) and four non-small-cell (NSCLC) lung cancer cell lines were used to examine the in vitro cytotoxicity… 
2003
2003
Formal enantiospecific synthesis of (+)-FR900482.
The enantiospecific synthesis of FK973, and thus a formal enantiospecific synthesis of the antitumor antibiotic (+)-FR900482, is… 
2003
2003
Interstrand cross-linking of DNA by FK317 and its deacetylated metabolites FR70496 and FR157471.
FR900482 (1) and FR66979 (2) are structurally novel natural products isolated by Fujisawa in 1987 and have been shown to be… 
1998
1998
FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome
Purpose: FK973, a substituted dihydrobenzoxazine, is an antitumor antibiotic which has shown high therapeutic efficacy in a phase… 
1994
1994
Microbial mutagenicity and in vitro chromosome aberration induction by FK973, a new antitumor agent.
1991
1991
Phase I trial of FK973: Description of a delayed vascular leak syndrome
SummaryFK973 is a novel, substituted dihydrobenzoxazine structurally similar to mitomycin. FK973 lacks cross-resistance with… 
1989
1989
Effect of FK973, a new antitumor antibiotic, on the cell cycle of L1210 cells in vitro.
Our previous study showed that FK973 (11-acetyl-8-carbamoyloxymethyl-4-formyl-14-oxa-1,11- diazatetracyclo[7.4.1.0(2,7)0(10,12… 
1989
1989
A new antitumor antibiotic, FK973: its metabolism in the blood and the antitumor effects of its metabolites on experimental models.
Our previous studies showed that a new, substituted dihydrobenzoxazine, FK973 (11-acetyl-8-carbamoyloxymethyl-4-formyl-14-oxa-1… 
1988
1988
Antitumor activity and hematotoxicity of a new, substituted dihydrobenzoxazine, FK973, in mice.
FK973, a new, substituted dihydrobenzoxazine (11-acetyl-8-carbamoyloxymethyl-4-formyl-14-oxa-1,11- diazatetracyclo[7.4.1.0.0… 
1988
1988
Interstrand DNA-DNA and DNA-protein cross-links by a new antitumor antibiotic, FK973, in L1210 cells.
In our previous study FK973, a novel, substituted dihydrobenzoxazine (11-acetyl-8-carbamoyloxymethyl-4-formyl-14-oxa-1,11… 
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