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FERMT2 gene

Known as: kindlin-2, Fermitin Family Member 2 Gene, MIG2 
This gene is involved in focal adhesion formation.
National Institutes of Health

Related topics

Related topics

5 relations
Cell-Matrix JunctionFERMT3 geneFermitin Family Homolog 2, humanPLEKHB1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Kindlin-2 links mechano-environment to proline synthesis and tumor growth
Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to… 
Highly Cited
2017
Highly Cited
2017
Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading
Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extracellular… 
Highly Cited
2016
Highly Cited
2016
Kindlin-2 directly binds actin and regulates integrin outside-in signaling
Bledzka et al. show that kindlin-2 binds actin via its F0 domain, and mutation of this site diminishes cell spreading, revealing… 
Highly Cited
2015
Highly Cited
2015
Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9.
Highly Cited
2014
Highly Cited
2014
Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation
ABSTRACT Kindlins are essential FERM-domain-containing focal adhesion (FA) proteins required for proper integrin activation and… 
Highly Cited
2013
Highly Cited
2013
Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis.
Activation of TGF-β/Smad signaling plays a central role in the pathogenesis of tubulointerstitial fibrosis, but the mechanisms… 
Highly Cited
2012
Highly Cited
2012
Distinct Roles of Talin and Kindlin in Regulating Integrin α5β1 Function and Trafficking
Highly Cited
2011
Highly Cited
2011
Osteoblast mineralization requires β1 integrin/ICAP-1–dependent fibronectin deposition
The morphogenetic and differentiation events required for bone formation are orchestrated by diffusible and insoluble factors… 
Highly Cited
2010
Highly Cited
2010
Kindlin‐2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
Kindlin‐2 is a novel integrin‐interacting focal adhesion protein that belongs to the Kindlin family. Focal adhesion proteins… 
Highly Cited
2008
Highly Cited
2008
Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3
BackgroundExpression of a large number of yeast genes is repressed by glucose. The zinc finger protein Mig1 is the main effector… 
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