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Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
TLDR
Using multiple mouse in vivo thrombosis models, it is demonstrated that genetic deletion of Cd36 protects mice from hyperlipidemia-associated enhanced platelet reactivity and the accompanying prothrombotic phenotype. Expand
Oxidative stress in angiogenesis and vascular disease.
TLDR
This review aims to provide a summary of the past and present views on the role of oxidative stress as a mediator and modulator of angiogenesis, and to highlight newly identified mechanisms. Expand
A mechanism for modulation of cellular responses to VEGF: activation of the integrins.
TLDR
Integrin activation provides a mechanism for VEGF to induce a broad spectrum of cellular responses and is identified as a basis for these interrelationships. Expand
Platelet GPIIb-IIIa blockers
TLDR
The GPIIb-IIIa blockers are taking the clinician and patient out of the era of aspirin monotherapy when platelet inhibition is required, with attention to heparin dose the risk of bleeding is not a major concern with these agents. Expand
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
TLDR
It is shown that Akt1 is the predominant isoform in vascular cells and the unexpected consequences ofAkt1 knockout on vascular integrity and pathological angiogenesis are described, establishing a crucial role of an Akt-thrombospondin axis in angiogenicogenesis. Expand
Integrin signaling is critical for pathological angiogenesis
TLDR
Novel mechanistic insights are provided into the role of integrin–VEGF axis in pathological angiogenesis and defective tyrosine phosphorylation in mutant β3 knock-in cells resulted in impaired adhesion, spreading, and migration of endothelial cells. Expand
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
TLDR
These findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis. Expand
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
TLDR
A genetic disease in two human siblings that presented with severe bleeding, frequent infections and osteopetrosis at an early age is identified and an essential role of KINDLIN-3 in integrin activation in humans is established. Expand
Mechanisms of Integrin–Vascular Endothelial Growth Factor Receptor Cross-Activation in Angiogenesis
TLDR
The present study determines the molecular mechanisms and consequences of the synergism between 2 cell surface receptor systems, growth factor receptor and integrins, and opens new avenues for the development of pro- and antiangiogenic strategies. Expand
Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis
TLDR
Several possible mechanisms reported by different labs which mediate formation of the complex between VEGFR-2 and αvβ3 on endothelial cells are discussed. Expand
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