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FCN2 protein, human

Known as: P35 ficolin protein, human, GlcNAc-binding lectin p35, human, ficolin 2 protein, human 
National Institutes of Health

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4 relations
FCN2 gene

Broader (3)

LectinPhytohemagglutininsficolin

Papers overview

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2018
2018
SPP1 and AGER as potential prognostic biomarkers for lung adenocarcinoma
Overdue treatment and prognostic evaluation lead to low survival rates in patients with lung adenocarcinoma (LUAD). To date… 
2017
2017
Ficolin‐A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis
Human ficolin‐2 (FCN‐2) and mouse ficolin‐A (FCN‐A, a ficolin‐2‐like molecule in mouse) are activators of the lectin complement… 
Highly Cited
2013
Highly Cited
2013
Natural IgG antibodies provide innate protection against ficolin‐opsonized bacteria
For nearly five decades since its discovery, the role of natural IgG, which pre‐exists in neonates and uninfected individuals… 
2012
2012
Genetic Evidence of Functional Ficolin-2 Haplotype as Susceptibility Factor in Cutaneous Leishmaniasis
Background Ficolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study… 
2011
2011
Functional Characterization of a Ficolin-mediated Complement Pathway in Amphioxus*
The ficolin-mediated complement pathway plays an important role in vertebrate immunity, but it is not clear whether this pathway… 
2010
2010
Carbohydrate recognition and complement activation by rat ficolin-B
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells. Humans produce two serum forms (L… 
Review
2010
Review
2010
Paths reunited: Initiation of the classical and lectin pathways of complement activation.
2007
2007
l‐Ficolin binding and lectin pathway activation by acetylated low‐density lipoprotein
l‐Ficolin, like mannan‐binding lectin (MBL), is a lectin pathway activator present in normal human plasma. Upon binding ligand, l… 
2007
2007
Identification of a functionally relevant signal peptide of mouse ficolin A.
Mouse ficolin A is a plasma protein with lectin activity, and plays a role in host defense by binding carbohydrates, especially… 
Highly Cited
2006
Highly Cited
2006
Small Mannose-Binding Lectin-Associated Protein Plays a Regulatory Role in the Lectin Complement Pathway1
Mannose-binding lectin (MBL) and ficolins are pattern recognition proteins acting in innate immunity, and they trigger the… 
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