FANCONI ANEMIA, COMPLEMENTATION GROUP J
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It has been proposed that guanine-rich DNA forms four-stranded structures in vivo called G-quadruplexes or G4 DNA. G4 DNA has… Expand Background: The Fe-S helicase FANCJ implicated in Fanconi anemia plays important roles in DNA replication and repair. Results… Expand It is clear that FANCJ, also known as BACH1 or BRIP1, is an essential tumor suppressor gene based on the identification of… Expand Bloom's syndrome (BS) and Fanconi anemia (FA) are autosomal recessive disorders characterized by cancer and chromosomal… Expand The XPD (xeroderma pigmentosum complementation group D) helicase family comprises a number of superfamily 2 DNA helicases with… Expand ABSTRACT FANCJ mutations are associated with breast cancer and genetically linked to the bone marrow disease Fanconi anemia (FA… Expand Abstract.The FANCJ family of DNA helicases is emerging as an important group of proteins for the prevention of human disease… Expand Recent reports have shown that mutations in the FANCJ/BRIP1 and FANCN/PALB2 Fanconi Anemia (FA) genes confer a moderate breast… Expand The protein predicted to be defective in individuals with Fanconi anemia complementation group J (FA-J), FANCJ, is a missing… Expand We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit… Expand