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F14512

National Institutes of Health

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2 relations
analogs & derivatives

Broader (1)

podofilox

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The DNA-Binding Polyamine Moiety in the Vectorized DNA Topoisomerase II Inhibitor F14512 Alters Reparability of the Consequent Enzyme-Linked DNA Double-Strand Breaks
Poisons of topoisomerase II (TOP2) kill cancer cells by preventing religation of intermediate DNA breaks during the enzymatic… 
2016
2016
Abstract 4185: Randomized double-blind clinical study of F14512, a new polyamine-vectorized anticancer drug and Etoposide in naturally occurring canine lymphoma
F14512 is a new topoisomerase II inhibitor containing a spermine moiety that facilitates selective uptake by tumor cells and… 
2015
2015
Abstract 2428: Translational study of F14512, a novel vectorised epipodophyllotoxin, which demonstrates a marked activity on ovarian cancer models from patients
Epithelial ovarian cancer is the fourth cause of death among cancer-bearing women, frequently associated with carboplatin… 
2014
2014
A New Generation of Cell-Targeted Drugs for Cancer Treatment
2012
2012
Abstract 2747: Synergistic antileukemic activity of F14512 in combination with AraC
New antileukemic agents are urgently needed to achieve improvement of the survival of patients suffering from Acute Myelogenous… 
2012
2012
Abstract 3799: Polyamine Transport System (PTS) activity and hijacking in cancer cells: New option in Head and Neck tumors treatment with the polyamine-containing drug candidate F14512
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL The Polyamine Transport System, although not… 
2011
2011
An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II
F14512 is a novel anti-tumor molecule based on an epipodophyllotoxin core coupled to a cancer-cell vectoring spermine moiety… 
2011
2011
Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II
F14512, an epipodophyllotoxin derivative equipped with a spermine moiety, is selectively taken up by the polyamine transport… 
2009
2009
Abstract #1701: Potent antitumor effect of F14512, a novel targeted cytotoxic agent, in an orthotopic glioblastoma model, as evaluated with non invasive optical imaging using in vivo bioluminescence…
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO The Polyamine Transport System (PTS) is an energy-dependent machinery… 
2007
2007
Preclinical antitumor activity of F14512, a novel targeted cytotoxic agent
A276 A novel approach for the selective targeting of a potent cytotoxic agent to cancer cells is proposed. The strategy consists… 
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