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Excitatory Amino Acid Transporter 1

Known as: Transporter, SLC1A3, GLAST-1 Glutamate Aspartate Transporter, SLC1A3 Transporter 
A glial type glutamate plasma membrane transporter protein found predominately in ASTROCYTES. It is also expressed in HEART and SKELETAL MUSCLE and… Expand
National Institutes of Health

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In BloodProcess of secretionSLC1A3 geneagonists
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Papers overview

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Review
2019
Review
2019
The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS) which initiates rapid signal… Expand
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Highly Cited
2018
Highly Cited
2018
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors
As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation1–4. However, the limiting… Expand
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2017
2017
Involvement of the glutamate/glutamine cycle and glutamate transporter GLT-1 in antidepressant-like effects of Xiao Yao san on chronically stressed mice
  • X. Ding, Y. Li, +4 authors Yan Zhou
  • BMC Complementary and Alternative Medicine
  • 2017
    • Corpus ID: 19497048
BackgroundXiao Yao San (XYS) is an herbal prescription which is used in the treatment of depression for thousands of years from… Expand
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2015
2015
Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1)*
Background: The mechanism for transcriptional regulation of EAAT1 remains to be elucidated. Results: EGF-activated NF-κB is a… Expand
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Highly Cited
2013
Highly Cited
2013
Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that are… Expand
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2011
2011
Ceftriaxone Preconditioning Confers Neuroprotection in Neonatal Rats Through Glutamate Transporter 1 Upregulation
Objective: This study investigated the hypothesis that ceftriaxone preconditioning ameliorates brain damage in neonatal animals… Expand
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Highly Cited
2008
Highly Cited
2008
Loss of Glial Glutamate and Aspartate Transporter (Excitatory Amino Acid Transporter 1) Causes Locomotor Hyperactivity and Exaggerated Responses to Psychotomimetics: Rescue by Haloperidol and…
BACKGROUND Recent data suggest that excessive glutamatergic signaling in the prefrontal cortex may contribute to the… Expand
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Highly Cited
2005
Highly Cited
2005
A novel alternative splicing form of excitatory amino acid transporter 1 is a negative regulator of glutamate uptake
EAAT1 is a major glutamate transporter in the CNS and is required for normal neurotransmission and neuroprotection from… Expand
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2004
2004
Expression of Excitatory Amino Acid Transporter‐1 (EAAT‐1) in Brain Macrophages and Microglia of Patients with Prion Diseases
The mechanisms of neuronal apoptosis in prion diseases are unclear. Experimental studies suggest that it may result from 2… Expand
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Highly Cited
2003
Highly Cited
2003
Transcriptional regulation of human excitatory amino acid transporter 1 (EAAT1): cloning of the EAAT1 promoter and characterization of its basal and inducible activity in human astrocytes
Excitatory amino acid transporter 1 (EAAT1) is one of the two glial glutamate transporters that clear the extracellular glutamate… Expand
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