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Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Background: The deposition of the amyloid β protein (Aβ) is a histopathologic hallmark of AD. The regions of the medial temporal lobe (MTL) are hierarchically involved in Aβ-deposition. Objective: ToExpand
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Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Two thousand three hundred and thirty two nonselected brains from 1- to 100-year-old individuals were examined using immunocytochemistry (AT8) and Gallyas silver staining for abnormal tau;Expand
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Primary age-related tauopathy (PART): a common pathology associated with human aging
We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains withExpand
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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative syndrome hallmarked by adult-onset loss of motor neurons. We performed exome sequencing of 252 familial ALS (fALS)Expand
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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Abstract Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potentialExpand
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Two Types of Sporadic Cerebral Amyloid Angiopathy
Cerebral amyloid angiopathy (CAA) is a type of β-amyloidosis that occurs in leptomeningeal and cortical vessels of the elderly. In a sample of 41 CAA cases including 16 Alzheimer disease (AD) casesExpand
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Review: sporadic cerebral amyloid angiopathy.
Cerebral amyloid angiopathy (CAA) may result from focal to widespread amyloid-β protein (Aβ) deposition within leptomeningeal and intracortical cerebral blood vessels. In addition, pericapillary AβExpand
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Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β-protein (Aβ) within cerebral vessels. The involvement of different brain areas in CAA follows a hierarchicalExpand
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Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence isExpand
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TDP-43 is intercellularly transmitted across axon terminals
A protein complementation assay quantifying TDP-43 oligomerization in living neurons shows microvesicular and bidirectional synaptic transmission of TDP-43 and TDP-43 seeding activity in human ALSExpand
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