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Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Known as: EFTs, Ewing Family of Tumors, Ewing's Family of Tumours 
A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing… Expand
National Institutes of Health

Related topics

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17 relations
AnemiaEWSR1 geneEWSR1 wt AlleleEWSR1-PATZ1 Fusion Protein Expression
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Papers overview

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Highly Cited
2011
Highly Cited
2011
R1507, a monoclonal antibody to the insulin-like growth factor 1 receptor, in patients with recurrent or refractory Ewing sarcoma family of tumors: results of a phase II Sarcoma Alliance for Research…
PURPOSE The type 1 insulin-like growth factor 1 receptor (IGF-1R) has been implicated in the pathogenesis of the Ewing sarcoma… Expand
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Highly Cited
2011
Highly Cited
2011
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.
BACKGROUND Chromosomal translocations generating oncogenic transcription factors are the hallmark of a variety of tumors… Expand
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Highly Cited
2009
Highly Cited
2009
Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study.
PURPOSE The Ewing sarcoma family of tumors (ESFT) is a group of malignant tumors of soft tissue and bone sharing a chromosomal… Expand
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2008
2008
Primary Ewing sarcoma/peripheral primitive neuroectodermal tumor of the vulva.
We report a case of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) arising in the vulva in a 17-year-old… Expand
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Review
2005
Review
2005
Ewing Sarcoma Family of Tumors
  • J. Khoury
  • Advances in anatomic pathology
  • 2005
    • Corpus ID: 20939021
The Ewing sarcoma family of tumors (ESFT) comprises morphologically heterogeneous tumors that are characterized by nonrandom… Expand
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Highly Cited
1998
Highly Cited
1998
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II
As a result of the t(11;22)(q24;q12) chromosomal translocation characterizing the Ewing family of tumors (ET), the amino terminal… Expand
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Review
1997
Review
1997
The Ewing family of tumors. Ewing's sarcoma and primitive neuroectodermal tumors.
  • H. Grier
  • Pediatric clinics of North America
  • 1997
    • Corpus ID: 40024090
There has been an explosion of new knowledge regarding the Ewing family of tumors over the past 5 to 10 years. Classical Ewing's… Expand
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Highly Cited
1997
Highly Cited
1997
Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors
The pRB cell cycle regulatory cascade is frequently perturbed in neoplasia by overexpression of a component of the pRB… Expand
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Highly Cited
1994
Highly Cited
1994
The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts.
BACKGROUND Precise diagnosis of small-round-cell tumors is often a challenge to the pathologist and the clinical oncologist. In… Expand
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Highly Cited
1994
Highly Cited
1994
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains.
The EWS gene, which maps to band q12 of human chromosome 22, is involved in a wide variety of human solid tumors including Ewing… Expand
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