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Eukaryotic Translation Initiation Factor 2 Subunit 1

Known as: Eukaryotic Translation Initiation Factor 2 Subunit Alpha, eIF-2alpha, eIF-2-alpha 
Eukaryotic translation initiation factor 2 subunit 1 (315 aa, ~36 kDa) is encoded by the human EIF2S1 gene. This protein plays a role in the… 
National Institutes of Health

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3 relations
EIF2S1 geneEIF2S1 wt AlleleGenetic Translation Process

Papers overview

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1998
1998
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase.
Genomic and cDNA clones homologous to the yeast GCN2 eIF-2alpha kinase (yGCN2) were isolated from Drosophila melanogaster. The… 
1997
1997
Developmental regulation of a plant encoded inhibitor of eukaryotic initiation factor 2 alpha phosphorylation.
An inhibitor of eIF-2a phosphorylation was identified in various plant species. The plant protein (termed PKI) specifically cross… 
Review
1996
Review
1996
Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells.
Highly Cited
1991
Highly Cited
1991
Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum.
A cell-free protein-synthesizing system has been reconstituted using the S-30 fraction or ribosomes and the S-100 fraction from… 
Review
1989
Review
1989
The 90,000 dalton heat shock protein, a lot of smoke but no function as yet.
What does the 90 000 dalton heat shock protein (hsp 90) really do? What cellular function does it carry out that is… 
1981
1981
Characterization of purified double-stranded RNA-activated eIF-2 alpha kinase from rabbit reticulocytes.
The initiation of protein synthesis in reticulocyte lysates is inhibited by low levels (1-50 ng/ml) of doublestranded RNA (dsRNA… 
1981
1981
Mechanism of interferon action: inhibition of pppA(2'p5'A)n-dependent ribonucleases activity in micrococcal nuclease-treated mouse L cell-free extracts.
1980
1980
Protein synthesis in rabbit reticulocytes. Demonstration of the requirements for eIF-2 and Co-eIF-2A for peptide chain initiation using immune sera.
Antisera to eIF-2 and Co-eIF-2A have been prepared by immunizing two chickens separately with homogeneous preparations of either… 
1980
1980
Indirect inactivation of eukaryotic initiation factor 2 in reticulocyte lysate by selenite.
1979
1979
Evidence that a single GTP is used in the formation of 80 S initiation complexes.
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