Eukaryotic Translation Initiation Factor 2 Subunit 1

Known as: Eukaryotic Translation Initiation Factor 2 Subunit Alpha, eIF-2alpha, eIF-2-alpha 
Eukaryotic translation initiation factor 2 subunit 1 (315 aa, ~36 kDa) is encoded by the human EIF2S1 gene. This protein plays a role in the… (More)

Topic mentions per year

Topic mentions per year

1978-2012
0519782012

Papers overview

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Highly Cited
2009
Highly Cited
2009
The endoplasmic reticulum (ER) unfolded protein response (UPR) restores equilibrium to the ER, but prolonged expression of the… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND & AIMS Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are associated with known triggers of… (More)
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Highly Cited
2007
Highly Cited
2007
It is not known how influenza A viruses, important human pathogens, counter PKR activation, a crucial host antiviral response… (More)
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Highly Cited
2000
Highly Cited
2000
A family of protein kinases regulates translation in response to different cellular stresses by phosphorylation of the alpha… (More)
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1999
1999
Eukaryotic translation initiation factor 2alpha (eIF-2alpha), a target molecule of the interferon-inducible double-stranded-RNA… (More)
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Highly Cited
1999
Highly Cited
1999
In response to environmental stress, the related RNA-binding proteins TIA-1 and TIAR colocalize with poly(A)(+) RNA at… (More)
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Highly Cited
1999
Highly Cited
1999
The double-stranded (ds) RNA-dependent protein kinase (PKR) is a key mediator of antiviral effects of interferon (IFN) and an… (More)
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Highly Cited
1998
Highly Cited
1998
In response to various environmental stresses, eukaryotic cells down-regulate protein synthesis by phosphorylation of the alpha… (More)
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Highly Cited
1998
Highly Cited
1998
In herpes simplex virus-infected cells, viral gamma134.5 protein blocks the shutoff of protein synthesis by activated protein… (More)
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1997
1997
Several translation initiation factors in mammals and yeast are regulated by phosphorylation. The phosphorylation state of these… (More)
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