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Ethyol

National Institutes of Health

Related topics

Related topics

8 relations

Broader (3)

AmifostineAmifostine TrihydrateRadiation-Protective Agents
Amifostine 500 MG Injection [Ethyol]Amifostine Injection [Ethyol]

Narrower (3)

AminopropylaminoethylthiophosphateNSC 327729WR 77913

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Tissue Levels of WR-1065, the Active Metabolite of Amifostine (Ethyol®), Are Equivalent following Intravenous or Subcutaneous Administration in Cynomolgus Monkeys
Amifostine (Ethyol®) is a cytoprotective drug approved for the reduction of xerostomia in head and neck cancer when administered… 
Highly Cited
2002
Highly Cited
2002
Preclinical modeling of improved amifostine (Ethyol) use in radiation therapy.
Amifostine (Ethyol) has been evaluated clinically as a radioprotective agent for the prevention of xerostomia and mucositis for… 
Highly Cited
2001
Highly Cited
2001
Subcutaneous administration of amifostine: a promising therapeutic option in patients with oxaliplatin-related peripheral sensitive neuropathy.
Oxaliplatin, a third-generation platinum compound with a 1,2-diaminocyclohexane (DACH) carrier ligand, is a recently developed… 
Highly Cited
2000
Highly Cited
2000
A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma.
Highly Cited
2000
Highly Cited
2000
In vitro antioxidant properties of amifostine (WR-2721, Ethyol)
Purpose: Amifostine (WR-2721), a phosphorylated aminothiol pro-drug which is an analogue of cysteamine, is a selective… 
Highly Cited
1997
Highly Cited
1997
Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage.
The main metabolites of the cytoprotective drug Ethyol (Amifostine, WR-2721) are the thiol WR-1065 and the disulphide WR-33278… 
Review
1994
Review
1994
Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.
Amifostine (WR-2721, S-2 [3-aminopropylamino]-ethylphosphorothioic acid; Ethyol, US Bioscience, Inc. West Conshohocken, PA… 
Review
1994
Review
1994
Radiotherapeutic studies with amifostine (Ethyol).
Radiotherapeutic studies with amifostine (WR-2721; Ethyol, US Bioscience, Inc, West Conshohocken, PA) are reviewed, with evidence… 
Highly Cited
1994
Highly Cited
1994
Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse.
This study investigated the metabolism of the radio- and chemoprotector compound, WR-2721 [amifostine; s-2-(3- aminopropylamino… 
Review
1994
Review
1994
Protection of normal tissues from the cytotoxic effects of chemotherapy by amifostine (Ethyol): clinical experiences.
The rationale for the clinical trials with amifostine (Ethyol, US Bioscience, Inc, West Conshohocken, PA) is based on an… 
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