Amifostine

Known as: Amifostine [Chemical/Ingredient], Apaetp, 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester 
The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
05010019702018

Papers overview

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2009
2009
Despite an encouraging outcome of antioxidant therapy in animal models of acute lung injury, effective antioxidant agents for… (More)
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2005
2005
Cisplatin in higher doses have been used routinely in the treatment of childhood tumours including neuroblastoma and germ cell… (More)
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2002
2002
PURPOSE To determine the prophylactic properties of amifostine against acute and late toxicities from radiochemotherapy in… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE Amifostine (WR-2721) is an important cytoprotective agent. Although intravenous administration is the standard route… (More)
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1998
1998
BACKGROUND Amifostine has reduced toxicities associated with radiation therapy and platinum-based chemotherapy. In a phase II… (More)
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1997
1997
The aminothiol, amifostine (Ethyol; U.S. Bioscience, West Conshohocken, PA), is a cytoprotective agent that ameliorates the… (More)
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Highly Cited
1996
Highly Cited
1996
PURPOSE Serious cumulative toxicity is a well-recognized consequence of chemotherapy. Amifostine, an organic thiophosphate, has… (More)
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1996
1996
Controlled clinical trials indicate that amifostine (WR-2721, Ethyol) confers protection from the cumulative hematologic… (More)
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Highly Cited
1985
Highly Cited
1985
Addition of alkaline phosphatase and WR-2721 to culture medium containing V79-171 cells leads to production of WR-1065 and its… (More)
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1980
1980
This report summarizes the present status of the proposed use of WR-2721 (S-2-(3-aminopropylamino)-ethylphosphorothioic acid… (More)
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