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Amifostine
Known as:
Amifostine [Chemical/Ingredient]
, APAETP
, 2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester
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The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free…
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National Institutes of Health
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Related topics
Related topics
23 relations
Amifostine 500 MG Injection [Ethyol]
Drug Allergy
Drug toxicity
Free Radical Scavenging Activity [MoA]
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Narrower (10)
Amifostine Trihydrate
Aminopropylaminoethylthiophosphate
Ethiofos
Ethyol
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Broader (1)
Radiation-Protective Agents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1986
1986
Final report of the phase I trial of single-dose WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid].
A. Turrisi
,
D. Glover
,
+5 authors
M. Kligerman
Cancer treatment reports
1986
Corpus ID: 26523961
Two hundred one patients were entered in a single-dose phase I trial of WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic…
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1986
1986
Protection of mouse chromosomes against whole-body gamma irradiation by SH-compounds.
R. Gupta
,
P. Uma Devi
British Journal of Radiology
1986
Corpus ID: 36249773
Of the several chemicals considered for radioprotection, WR-2721 (S-2-(3-aminopropylamino)phosphorothioic acid), a derivative of…
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1985
1985
Interactions of radioprotectors and oxygen in cultured mammalian cells. I. Dithiothreitol effects on radiation-induced cell killing.
K. Held
Radiation Research
1985
Corpus ID: 39194060
Radioprotection in vitro by sulfhydryl (SH)-containing compounds is usually greater in aerated than in hypoxic cells. This…
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1985
1985
Treatment of hypercalcemia in parathyroid cancer with WR-2721, S-2-(3-aminopropylamino)ethyl-phosphorothioic acid.
D. Glover
,
L. Shaw
,
+4 authors
S. Goldfarb
Annals of Internal Medicine
1985
Corpus ID: 31390449
The chemoprotective and hypocalcemic agent WR-2721, S-2-(3-aminopropylamino) ethyl-phosphorothioic acid, inhibits parathyroid…
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1983
1983
Radioprotection of the rat parotid gland by WR-2721 and isoproterenol and its modification by propranolol.
M. Sodicoff
,
A. D. Conger
Radiation Research
1983
Corpus ID: 424063
The aminothiol WR-2721 and beta-adrenergic agonist isoproterenol both conferred considerable radioprotection to the rat parotid…
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1983
1983
Modification of stromal radiosensitivity by misonidazole and WR-2721.
A. Begg
,
N. Terry
British Journal of Radiology
1983
Corpus ID: 21471138
The radiosensitivity of normal vascular connective tissue has been assessed by measuring the growth rate of untreated tumours…
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1983
1983
Protection by S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation-induced leg contractures in mice.
N. Hunter
,
L. Milas
Cancer Research
1983
Corpus ID: 19121661
S-2-(3-Aminopropylamino)ethylphosphorothioic acid (WR-2721) was shown to provide marked protection against development of…
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1982
1982
Radioprotection of mouse skin by WR-2721 in single and fractionated treatments.
F. Stewart
,
A. Rojas
British Journal of Radiology
1982
Corpus ID: 31472599
The radioprotective action of WR-2721 on mouse skin has been studied using single doses, two and five fractions. Significant…
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1976
1976
Chemoprotection against fractionated radiation exposures with WR-2721: skin injury.
F. Echols
,
J. Yuhas
Radiation Research
1976
Corpus ID: 12980664
These studies extend the analysis of the potential application of WR-2721 (S-2-(3-aminopropylamino)ethylphosphorothioic acid) to…
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Highly Cited
1970
Highly Cited
1970
Biological factors affecting the radioprotective efficiency of S-2-[2-aminopropylamino] ethylphosphorothioic acid (WR-2721). LD50(3)) doses.
J. Yuhas
Radiation Research
1970
Corpus ID: 11781267