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Ethylnitrosourea
Known as:
N-ETHYL-N-NITROSOUREA
, N-Nitroso-N-Ethylurea
, Nitrosoethylurea
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A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins…
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National Institutes of Health
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Related topics
Related topics
9 relations
Narrower (3)
1,3-diethyl-1-nitrosourea
chloroethylnitrosocarbamoyl-alanyl-alanine
chloroethylnitrosocarbamoyl-glycinemethylamide
Broader (1)
Alkylating Agents
NCIt Antineoplastic Agent Terminology
analogs & derivatives
aspects of radiation effects
chemical synthesis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
B. Beutler
,
Zhengfan Jiang
,
+5 authors
K. Hoebe
Annual review of immunology
2006
Corpus ID: 20991617
Classical genetic methods, driven by phenotype rather than hypotheses, generally permit the identification of all proteins that…
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Review
2005
Review
2005
Nitrogen metabolism in the rumen.
A. Bach
,
S. Calsamiglia
,
M. Stern
Journal of dairy science
2005
Corpus ID: 22984916
Protein metabolism in the rumen is the result of metabolic activity of ruminal microorganisms. The structure of the protein is a…
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Highly Cited
2000
Highly Cited
2000
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
M. H. Angelis
,
H. Flaswinkel
,
+34 authors
R. Balling
Nature Genetics
2000
Corpus ID: 1070319
In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large…
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Highly Cited
1996
Highly Cited
1996
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.
O. Cohen-Fix
,
J. Peters
,
M. Kirschner
,
D. Koshland
Genes & development
1996
Corpus ID: 25738605
Anaphase initiation has been postulated to be controlled through the ubiquitin-dependent proteolysis of an unknown inhibitor…
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Review
1996
Review
1996
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
P. Haffter
,
M. Granato
,
+14 authors
C. Nüsslein-Volhard
Development
1996
Corpus ID: 5235078
In a large-scale screen, we isolated mutants displaying a specific visible phenotype in embryos or early larvae of the zebrafish…
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Highly Cited
1994
Highly Cited
1994
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
M. Vitaterna
,
D. P. King
,
+7 authors
J. Takahashi
Science
1994
Corpus ID: 31473202
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU…
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Highly Cited
1994
Highly Cited
1994
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate
M. Mullins
,
M. Hammerschmidt
,
P. Haffter
,
C. Nüsslein-Volhard
Current Biology
1994
Corpus ID: 7337194
Highly Cited
1990
Highly Cited
1990
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.
A. Moser
,
H. Pitot
,
W. Dove
Science
1990
Corpus ID: 19589453
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to…
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Highly Cited
1979
Highly Cited
1979
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
W. Russell
,
E. Kelly
,
P. Hunsicker
,
J. Bangham
,
S. Maddux
,
E. Phipps
Proceedings of the National Academy of Sciences…
1979
Corpus ID: 37429803
Use of the specific-locus test to measure the frequency of transmitted gene mutations induced in mouse spermatogonia has shown…
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Highly Cited
1974
Highly Cited
1974
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.
R. Goth
,
M. Rajewsky
Proceedings of the National Academy of Sciences…
1974
Corpus ID: 24494427
The nervous system specificity of the carcinogenic effect of N-ethyl-N-nitrosourea in rats at the perinatal age is of particular…
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