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Ethylnitrosourea

Known as: N-ETHYL-N-NITROSOUREA, N-Nitroso-N-Ethylurea, Nitrosoethylurea 
A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins… 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (3)

1,3-diethyl-1-nitrosoureachloroethylnitrosocarbamoyl-alanyl-alaninechloroethylnitrosocarbamoyl-glycinemethylamide

Broader (1)

Alkylating Agents
NCIt Antineoplastic Agent Terminologyanalogs & derivativesaspects of radiation effectschemical synthesis

Papers overview

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Highly Cited
2008
Highly Cited
2008
Development of an in vivo gene mutation assay using the endogenous Pig‐A gene: I. Flow cytometric detection of CD59‐negative peripheral red blood cells and CD48‐negative spleen T‐cells from the rat
The product of the phosphatidylinositol glycan complementation group A gene (Pig‐A) is involved in the synthesis of… 
Highly Cited
2008
Highly Cited
2008
In vivo mutation assay based on the endogenous Pig‐a locus
The product of the X‐chromosome's Pig‐a gene acts in the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis… 
Highly Cited
2000
Highly Cited
2000
Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource
Abstract. Systematic approaches to mouse mutagenesis will be vital for future studies of gene function. We have begun a major ENU… 
Review
1998
Review
1998
Mouse mutagenesis-systematic studies of mammalian gene function.
The mouse will play a pivotal role in mammalian gene function studies as we enter the post-genomics era. The challenge is to… 
Highly Cited
1997
Highly Cited
1997
Detection of DNA lesions induced by chemical mutagens using the single-cell gel electrophoresis (comet) assay. 2. Relationship between DNA migration and alkaline condition.
Highly Cited
1996
Highly Cited
1996
Gene interaction and single gene effects in colon tumour susceptibility in mice
To dissect the multigenic control of colon tumour susceptibility in the mouse1 we used the set of 20 CcS/Dem (CcS) recombinant… 
Review
1993
Review
1993
A review of the genotoxicity of 1-ethyl-1-nitrosourea.
Highly Cited
1991
Highly Cited
1991
Toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea in human cell lines with different DNA repair phenotypes.
We examined the toxicity, mutagenicity, and mutational spectra of N-ethyl-N-nitrosourea (ENU) in three Epstein-Barr virus… 
Highly Cited
1982
Highly Cited
1982
Induction of mutations and sister-chromatid exchanges in Chinese hamster ovary cells by ethylating agents.
Highly Cited
1980
Highly Cited
1980
Inability of Chinese hamster ovary cells to excise O6-alkylguanine.
The capacity of Chinese hamster ovary cells for excising alkylated bases from their DNA was investigated. Cells were treated with… 
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