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Ethylnitrosourea
Known as:
N-ETHYL-N-NITROSOUREA
, N-Nitroso-N-Ethylurea
, Nitrosoethylurea
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A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins…
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National Institutes of Health
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Related topics
Related topics
9 relations
Narrower (3)
1,3-diethyl-1-nitrosourea
chloroethylnitrosocarbamoyl-alanyl-alanine
chloroethylnitrosocarbamoyl-glycinemethylamide
Broader (1)
Alkylating Agents
NCIt Antineoplastic Agent Terminology
analogs & derivatives
aspects of radiation effects
chemical synthesis
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1987
Highly Cited
1987
Factors that affect the frequency of thioguanine-resistant lymphocytes in mice following exposure to ethylnitrosourea.
I. M. Jones
,
Karolyn Burkhart-Schultz
,
Cheryl L. Strout
,
Tawni L. Crippen
Environmental Mutagenesis
1987
Corpus ID: 2998507
The frequency of thioguanine(TG)-resistant lymphocytes in mice treated with ethylnitrosourea (ENU) was followed for a period of…
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1985
1985
Expression of monoclonal antibody-defined cell surface antigens during rat brain development.
A. Kindler-Röhrborn
,
O. Ahrens
,
U. Liepelt
,
M. Rajewsky
Differentiation; research in biological diversity
1985
Corpus ID: 23853611
Using single-cell suspensions of mechanically dissociated, prenatal BDIX-rat brain cells (13th, 15th, and 21st days after…
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1984
1984
Carcinogenicity of low doses of N-ethyl-N-nitrosourea in F344 rats; a dose-response study.
Akihiko Maekawa
,
Toshiaki Ogiu
,
+7 authors
Yuzo Hayashi
Gan
1984
Corpus ID: 19814643
The threshold level of minimum carcinogenic dose of N-ethyl-N-nitrosourea (ENU) and the effect of dose on organ specificity were…
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1983
1983
Antiteratogenic effects of tumor inhibitors, caffeine, antipain, and retinoic acid in mice.
Taisei Nomura
,
Takayuki Enomoto
,
+9 authors
Hiroko Gotoh
Cancer Research
1983
Corpus ID: 44261618
To learn the effects of tumor inhibitors on chemically induced malformations, caffeine, antipain, and 13-trans-retinoic acid were…
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1983
1983
Carcinogenicity of hydroxylated alkylnitrosoureas and of nitrosooxazolidones by mouse skin painting and by gavage in rats.
W. Lijinsky
,
M. D. Reuber
Cancer Research
1983
Corpus ID: 32733941
The carcinogenic effectiveness of a number of nitrosoalkylamides related to nitrosoethylurea and nitroso-n-propylurea has been…
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1983
1983
Immunohistochemical detection of O6-ethyldeoxyguanosine in the rat brain after in vivo applications of N-ethyl-N-nitrosourea.
C. Heyting
,
C. J. Van Der Laken
,
W. Raamsdonk
,
C. Pool
Cancer Research
1983
Corpus ID: 12051301
An immunohistochemical procedure was developed which allows the localization of the DNA lesion O6-ethyldeoxyguanosine (O6-EtdGuo…
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1983
1983
Carcinogenicity of single doses of N-nitroso-N-methylurea and N-nitroso-N-ethylurea in Syrian golden hamsters and the persistence of alkylated purines in the DNA of various tissues.
Alexei J. Likhachev
,
Mikhail N. Ivanov
,
Henriette Brésil
,
Ghyslaine Planche-Martel
,
Ruggero Montesano
,
Geoffrey P. Margison
Cancer Research
1983
Corpus ID: 8687524
The carcinogenicity of N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU) has been determined in adult male Syrian…
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Review
1982
Review
1982
The response of a variety of human fibroblast cell strains to the lethal effects of alkylating agents.
I.-A. Teo
,
C. Arlett
Carcinogenesis
1982
Corpus ID: 40412715
The sensitivities of fifteen human fibroblast cell strains to the lethal effects of alkylation damage produced by N-methyl-N…
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Highly Cited
1981
Highly Cited
1981
Tissue-dependent enzyme-mediated repair or removal of O-ethyl pyrimidines and ethyl purines in carcinogen-treated rats.
Brett C. Singer
,
S. Spengler
,
W. Bodell
Carcinogenesis
1981
Corpus ID: 30148665
Treatment of perinatal rats with N-ethyl-N-nitrosourea (EtNU) leads predominantly to brain tumors. The DNA in tissues of 10-day…
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Review
1979
Review
1979
Transplacental and neonatal induction of neurogenic tumors in mice: comparison with related species and with human pediatric neoplasms.
W. Wechsler
,
J. Rice
,
S. Vesselinovitch
National Cancer Institute monograph
1979
Corpus ID: 29661312
The literature on chemical induction and natural occurrence of neurogenic tumors in mice and some unpublished data from our…
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