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Ethylnitrosourea

Known as: N-ETHYL-N-NITROSOUREA, N-Nitroso-N-Ethylurea, Nitrosoethylurea 
A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins… 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (3)

1,3-diethyl-1-nitrosoureachloroethylnitrosocarbamoyl-alanyl-alaninechloroethylnitrosocarbamoyl-glycinemethylamide

Broader (1)

Alkylating Agents
NCIt Antineoplastic Agent Terminologyanalogs & derivativesaspects of radiation effectschemical synthesis

Papers overview

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Highly Cited
2014
Highly Cited
2014
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.
Highly Cited
1999
Highly Cited
1999
A large-scale insertional mutagenesis screen in zebrafish.
It is estimated that approximately 2500 genes are essential for the normal development of a zebrafish embryo. A mutation in any… 
Highly Cited
1998
Highly Cited
1998
The ability of the Comet assay to discriminate between genotoxins and cytotoxins.
The Comet assay has been used widely in genetic toxicology, radiation biology and medical and environmental research. This assay… 
Highly Cited
1998
Highly Cited
1998
Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small-molecular contrast media.
OBJECTIVE The endothelial integrity of microvessels is disrupted in malignant tumors. Quantitative assays of tumor microvascular… 
Highly Cited
1996
Highly Cited
1996
Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse
Many complex traits, including susceptibility to lung cancer, are controlled by multiple genes — quantitative trait loci (QTLs… 
Highly Cited
1991
Highly Cited
1991
Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.
Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated for use as a short-term, in vivo… 
Highly Cited
1985
Highly Cited
1985
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
Highly Cited
1982
Highly Cited
1982
Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas
Highly Cited
1978
Highly Cited
1978
Sister chromatid exchange as an indicator of mutagenesis
SISTER chromatid exchange (SCE), that is, the reciprocal interchange of DNA between chromatids, is easily visualised in metaphase… 
Highly Cited
1966
Highly Cited
1966
Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats
ALKYLNITROSOUREAS give the corresponding alkylating diazoalkanes on heterolysis, and are potent carcinogens, selectively… 
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