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Ethylnitrosourea

Known as: N-ETHYL-N-NITROSOUREA, N-Nitroso-N-Ethylurea, Nitrosoethylurea 
A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins… 
National Institutes of Health

Related topics

Related topics

9 relations

Narrower (3)

1,3-diethyl-1-nitrosoureachloroethylnitrosocarbamoyl-alanyl-alaninechloroethylnitrosocarbamoyl-glycinemethylamide

Broader (1)

Alkylating Agents
NCIt Antineoplastic Agent Terminologyanalogs & derivativesaspects of radiation effectschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
Classical genetic methods, driven by phenotype rather than hypotheses, generally permit the identification of all proteins that… 
Review
2005
Review
2005
Nitrogen metabolism in the rumen.
Protein metabolism in the rumen is the result of metabolic activity of ruminal microorganisms. The structure of the protein is a… 
Highly Cited
2000
Highly Cited
2000
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large… 
Highly Cited
1996
Highly Cited
1996
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.
Anaphase initiation has been postulated to be controlled through the ubiquitin-dependent proteolysis of an unknown inhibitor… 
Review
1996
Review
1996
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
In a large-scale screen, we isolated mutants displaying a specific visible phenotype in embryos or early larvae of the zebrafish… 
Highly Cited
1994
Highly Cited
1994
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU… 
Highly Cited
1994
Highly Cited
1994
Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate
Highly Cited
1990
Highly Cited
1990
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to… 
Highly Cited
1979
Highly Cited
1979
Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
Use of the specific-locus test to measure the frequency of transmitted gene mutations induced in mouse spermatogonia has shown… 
Highly Cited
1974
Highly Cited
1974
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.
  • R. Goth, M. Rajewsky
  • Proceedings of the National Academy of Sciences…
  • 1974
  • Corpus ID: 24494427
The nervous system specificity of the carcinogenic effect of N-ethyl-N-nitrosourea in rats at the perinatal age is of particular… 
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