Ethylnitrosourea

Known as: N-ETHYL-N-NITROSOUREA, N-Nitroso-N-Ethylurea, Nitrosoethylurea 
A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins… (More)
National Institutes of Health

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8 relations

Narrower (3)

1,3-diethyl-1-nitrosoureachloroethylnitrosocarbamoyl-alanyl-alaninechloroethylnitrosocarbamoyl-glycinemethylamide

Broader (1)

Alkylating Agents
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Highly Cited
2011
Highly Cited
2011
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses to viral and bacterial infections… (More)
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Highly Cited
2008
Highly Cited
2008
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation
X-chromosome inactivation is the mammalian dosage compensation mechanism by which transcription of X-linked genes is equalized… (More)
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Highly Cited
2007
Highly Cited
2007
Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression
Using a forward genetics ENU mutagenesis screen for recessive mutations that affect circadian rhythmicity in the mouse, we… (More)
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Highly Cited
2007
Highly Cited
2007
Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function.
OPA1 is a ubiquitously expressed, nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a… (More)
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Highly Cited
2007
Highly Cited
2007
Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans
The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect… (More)
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Review
2006
Review
2006
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.
Classical genetic methods, driven by phenotype rather than hypotheses, generally permit the identification of all proteins that… (More)
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Highly Cited
2005
Highly Cited
2005
A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection.
The retinotectal projection is a premier model system for the investigation of molecular mechanisms that underlie axon… (More)
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Highly Cited
2003
Highly Cited
2003
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth and maintenance of flagella in… (More)
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Highly Cited
2000
Highly Cited
2000
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
As the human genome project approaches completion, the challenge for mammalian geneticists is to develop approaches for the… (More)
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Highly Cited
1996
Highly Cited
1996
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.
Anaphase initiation has been postulated to be controlled through the ubiquitin-dependent proteolysis of an unknown inhibitor… (More)
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