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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
Known as:
EGFR Tyrosine Kinase Inhibitor
, EGFR Inhibitor
, EGFR Blocker
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Any tyrosine kinase inhibitor that targets the activity of the epidermal growth factor receptor (EGFR) tyrosine kinase. Inhibition of epidermal…
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National Institutes of Health
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Related topics
Related topics
2 relations
HER1 Antagonists [MoA]
Receptor Tyrosine Kinase Inhibition
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Strategies to Improve Outcomes of Patients with EGRF‐Mutant Non–Small Cell Lung Cancer: Review of the Literature
Caicun Zhou
,
Luan Di Yao
Journal of Thoracic Oncology
2016
Corpus ID: 24024311
Highly Cited
2013
Highly Cited
2013
Detection of epidermal growth factor receptor T790M mutation in plasma DNA from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor
K. Sakai
,
A. Horiike
,
+10 authors
K. Nishio
Cancer Science
2013
Corpus ID: 28528642
A secondary epidermal growth factor receptor (EGFR) mutation, the substitution of threonine 790 with methionine (T790M), leads to…
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Highly Cited
2012
Highly Cited
2012
Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors.
M. Nishino
,
Stephanie Cardarella
,
+6 authors
B. Johnson
Lung Cancer
2012
Corpus ID: 45059358
Highly Cited
2010
Highly Cited
2010
Cytochrome P450-Mediated Bioactivation of the Epidermal Growth Factor Receptor Inhibitor Erlotinib to a Reactive Electrophile
Xiaohai Li
,
T. Kamenecka
,
M. Cameron
Drug Metabolism And Disposition
2010
Corpus ID: 4812676
The epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (ERL) is approved for treatment of non–small-cell lung…
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Highly Cited
2008
Highly Cited
2008
Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer.
A. Jimeno
,
A. Tan
,
+12 authors
M. Hidalgo
Cancer Research
2008
Corpus ID: 23156300
The epidermal growth factor receptor (EGFR) inhibitor erlotinib is approved for treatment of pancreatic cancer but the overall…
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Highly Cited
2007
Highly Cited
2007
Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer.
Li Yang
,
J. Amann
,
+10 authors
David H. Johnson
Cancer Research
2007
Corpus ID: 30632384
Evidence indicates that the induction of cyclooxygenase-2 (COX-2) and high prostaglandin E2 (PGE2) levels contribute to the…
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2007
2007
The Intestinotrophic Peptide, GLP-2, Counteracts Intestinal Atrophy in Mice Induced by the Epidermal Growth Factor Receptor Inhibitor, Gefitinib
K. Hare
,
B. Hartmann
,
H. Kissow
,
J. Holst
,
S. Poulsen
Clinical Cancer Research
2007
Corpus ID: 34071690
Purpose: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors have been introduced as antitumor agents in the…
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Highly Cited
2005
Highly Cited
2005
Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation.
N. Di Girolamo
,
M. Coroneo
,
D. Wakefield
American Journal of Pathology
2005
Corpus ID: 43573709
Review
2003
Review
2003
Development of the epidermal growth factor receptor inhibitor OSI-774.
V. Grünwald
,
M. Hidalgo
Seminars in Oncology
2003
Corpus ID: 22302259
Highly Cited
2002
Highly Cited
2002
Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).
A. Heimberger
,
Chris A. Learn
,
+8 authors
J. Sampson
Clinical Cancer Research
2002
Corpus ID: 2830421
Iressa (ZD1839) is a p.o.-active, selective, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that blocks…
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