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Epidermal Growth Factor Receptor Pathway Substrate 8

Known as: EPS8, Epidermal Growth Factor Receptor Kinase Substrate EPS8 
Epidermal growth factor receptor pathway substrate 8; has a role in normal and neoplastic cell proliferation; contains an SH3 motif. (LocusLink)
National Institutes of Health

Related topics

Related topics

6 relations
Cell ProliferationEPS8 geneHomo sapiensSignal Transduction

Papers overview

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Highly Cited
2013
Highly Cited
2013
Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8
Summary Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development… 
Highly Cited
2011
Highly Cited
2011
Regulation of Stereocilia Length by Myosin XVa and Whirlin Depends on the Actin-Regulatory Protein Eps8
Highly Cited
2011
Highly Cited
2011
Eps8 Regulates Hair Bundle Length and Functional Maturation of Mammalian Auditory Hair Cells
Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into… 
Highly Cited
2010
Highly Cited
2010
Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping
The unusual dual functions of the actin-binding protein EPS8 as an actin capping and actin bundling factor are mapped to distinct… 
Highly Cited
2009
Highly Cited
2009
Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)
A novel signaling cascade controlling actin polymerization in response to extracellular signals regulates filopodia formation and… 
Highly Cited
2006
Highly Cited
2006
Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression.
To identify genetic changes involved in the progression of breast carcinoma, we did cDNA array comparative genomic hybridization… 
Highly Cited
2006
Highly Cited
2006
Supplemental Data Increased Ethanol Resistance and Consumption in Eps 8 Knockout Mice Correlates with Altered Actin Dynamics
Ethanol Induced Loss-of Righting Reflex Threshold. The threshold concentration of ethanol required to induce the loss of righting… 
Highly Cited
2004
Highly Cited
2004
IRSp53/Eps8 Complex Is Important for Positive Regulation of Rac and Cancer Cell Motility/Invasiveness
IRSp53 has been characterized as an adaptor protein that links Rho-family small GTPases, such as Rac, to reorganization of the… 
Highly Cited
2000
Highly Cited
2000
The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
How epidermal growth factor receptor (EGFR) signalling is linked to EGFR trafficking is largely unknown. Signalling and… 
Highly Cited
1997
Highly Cited
1997
Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth
Eps8, a substrate of receptor tyrosine kinases, is an SH3 domain containing protein that plays an important role in mitogenic… 
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