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Abi1 is essential for the formation and activation of a WAVE2 signalling complex
WAVE2 belongs to a family of proteins that mediates actin reorganization by relaying signals from Rac to the Arp2/3 complex, resulting in lamellipodia protrusion. WAVE2 displays Arp2/3-dependentExpand
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Sra‐1 and Nap1 link Rac to actin assembly driving lamellipodia formation
The Rho‐GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals to Scar/WAVE proteins leading to activation of Arp2/3‐mediated actin polymerization. Scar/WAVE proteins doExpand
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Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells
Actin polymerization-driven protrusion of the leading edge is a key element of cell motility. The important actin nucleators formins and the Arp2/3 complex are believed to have nonoverlappingExpand
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Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration
The small GTPases, Rab5 and Rac, are essential for endocytosis and actin remodeling, respectively. Coordination of these processes is critical to achieve spatial restriction of intracellularExpand
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  • Open Access
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1
Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, RacExpand
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  • Open Access
IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.
A tight spatiotemporal coordination of the machineries controlling membrane bending and trafficking, and actin dynamics is crucial for the generation of cellular protrusions. Proteins that areExpand
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Regulation of actin dynamics by WASP and WAVE family proteins.
Abstract Signal-dependent regulation of actin dynamics is essential for a variety of cellular processes, including formation of the membrane protrusions required for cell locomotion. Wiskott–AldrichExpand
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Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
Neural Wiskott–Aldrich syndrome protein (N-WASP) and WAVE are members of a family of proteins that use the Arp2/3 complex to stimulate actin assembly in actin-based motile processes. By entering intoExpand
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Protein complexes regulating Arp2/3-mediated actin assembly.
Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3Expand
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Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8–IRSp53 complex
Actin-crosslinking proteins organize actin into highly dynamic and architecturally diverse subcellular scaffolds that orchestrate a variety of mechanical processes, including lamellipodial andExpand
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