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FM1-43 Dye Behaves as a Permeant Blocker of the Hair-Cell Mechanotransducer Channel
Extracellular perfusion of FM1-43 reversibly blocks mechanotransduction with half-blocking concentrations in the low micromolar range and the time course for the relief of block after voltage steps to extreme potentials suggests that FM 1-43 competes with other cations for binding sites within the pore of the channel. Expand
Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells
Developmental changes in electrophysiological membrane properties of mouse cochlear inner hair cells (IHCs) were studied from just after terminal differentiation up to functional maturity, where they appear mature in terms of their complement of K+ conductances. Expand
The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano 
‐electrical transducer channels
It is reported that extracellular dihydrostreptomycin not only blocks the mechano‐electrical transducer channels of mouse outer hair cells at negative membrane potentials, but also enters the cells through these channels, which are located in the cells' mechanosensory hair bundles. Expand
Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells
The increasedCa2+ efficiency and linear Ca2+ dependence of mature IHC exocytosis, especially over the physiological range of intracellular Ca2+, could improve the high‐fidelity transmission of both brief and long‐lasting stimulation. Expand
Restoration of auditory evoked responses by human ES cell-derived otic progenitors
A protocol to induce differentiation from human embryonic stem cells (hESCs) using signals involved in the initial specification of the otic placode results in two types of otic progenitors able to differentiate in vitro into hair-cell-like cells and auditory neurons that display expected electrophysiological properties. Expand
Developmental expression of the potassium current IK,n contributes to maturation of mouse outer hair cells
It is concluded that ion channels underlying IK,n contain the KCNQ4 subunit, which is responsible for a form of non‐syndromic autosomal dominant deafness in OHCs and contributes to this maturation. Expand
Development and properties of stereociliary link types in hair cells of the mouse cochlea
There is a rich, rapidly changing array of different links covering the developing hair bundle that becomes progressively refined to generate the mature complement by P19, as indicated by the results of electron microscopy. Expand
Sodium and calcium currents shape action potentials in immature mouse inner hair cells
The Na+ current was downregulated around the onset of hearing, when the spiking is also known to disappear, and the size of both currents was positively correlated with the developmental change in action‐potential frequency. Expand
Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
It is shown that the efferent neurotransmitter acetylcholine fine-tunes the IHC's resting membrane potential (Vm), and as such is crucial for the bursting pattern in apical cells, and proposed that the difference in firing pattern along the cochlea instructs the tonotopic differentiation of IHCs and auditory pathway. Expand
A Receptor-Like Inositol Lipid Phosphatase Is Required for the Maturation of Developing Cochlear Hair Bundles
Results reveal that Ptprq is required for formation of the shaft connectors of the hair bundle, the normal maturation of cochlear hair bundles, and the long-term survival of high-frequency auditory hair cells. Expand