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Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2

Known as: Autotaxin-T, Extracellular Lysophospholipase D, Autotaxin 
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (863 aa, ~99 kDa) is encoded by the human ENPP2 gene. This protein plays a role in… 
National Institutes of Health

Related topics

Related topics

5 relations
ENPP2 geneEnzyme GeneEsterase GeneHydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Autotaxin in Pathophysiology and Pulmonary Fibrosis
Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis… 
Review
2015
Review
2015
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.
Highly Cited
2012
Highly Cited
2012
Depot-specific regulation of autotaxin with obesity in human adipose tissue
Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly… 
Highly Cited
2012
Highly Cited
2012
Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin.
Melanoma is the deadliest form of skin cancer in which patients with metastatic disease have a 5-year survival rate of less than… 
Review
2011
Review
2011
Insights into autotaxin: how to produce and present a lipid mediator
Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic acid (LPA). LPA acts through… 
Highly Cited
2007
Highly Cited
2007
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.
2007
2007
Secretion and lysophospholipase D activity of autotaxin by adipocytes are controlled by N-glycosylation and signal peptidase.
Highly Cited
2004
Highly Cited
2004
Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun
We have used chicken cDNA microarrays to investigate gene-expression changes induced during transformation of chick embryo… 
Highly Cited
1996
Highly Cited
1996
Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Autotaxin, a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human… 
Highly Cited
1994
Highly Cited
1994
cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.
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