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ENPP2 gene

Known as: AUTOTAXIN, Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 Gene, ATX 
This gene plays a role in the hydrolysis of lysophospholipids.
National Institutes of Health

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4 relations
ENPP2 protein, humanEctonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2Hydrolysis

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ENPP2 wt Allele

Papers overview

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Review
2014
Review
2014
Mechanisms regulating the development of oligodendrocytes and central nervous system myelin
Highly Cited
2012
Highly Cited
2012
Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic form of diffuse lung disease occurring mainly in older… 
Highly Cited
2011
Highly Cited
2011
Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid
Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). ATX is secreted… 
Review
2011
Review
2011
Insights into autotaxin: how to produce and present a lipid mediator
Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic acid (LPA). LPA acts through… 
Highly Cited
2009
Highly Cited
2009
Effective relief of neuropathic pain by adeno-associated virus-mediated expression of a small hairpin RNA against GTP cyclohydrolase 1
BackgroundRecent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is… 
Highly Cited
2005
Highly Cited
2005
Inhibition of Autotaxin by Lysophosphatidic Acid and Sphingosine 1-Phosphate*
Autotaxin (ATX) or nucleotide pyrophosphatase/phosphodiesterase 2 (NPP2) is an NPP family member that promotes tumor cell… 
Highly Cited
2003
Highly Cited
2003
Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation
Our group has recently demonstrated (Gesta, S., Simon, M., Rey, A., Sibrac, D., Girard, A., Lafontan, M., Valet, P., and Saulnier… 
Highly Cited
2001
Highly Cited
2001
Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification.
OBJECTIVE Elevated cartilage inorganic pyrophosphate (PPi) production and PPi-generating nucleoside triphosphate… 
Review
2000
Review
2000
Nucleotide Pyrophosphatases/Phosphodiesterases on the Move
Nucleotide pyrophosphatases/phosphodiesterases (NPPs) release nucleoside 5′-monophosphates from nucleotides and their derivatives… 
Highly Cited
1994
Highly Cited
1994
cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.
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