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ENPP2 gene

Known as: AUTOTAXIN, Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 Gene, ATX 
This gene plays a role in the hydrolysis of lysophospholipids.
National Institutes of Health

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ENPP2 protein, humanEctonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2Hydrolysis

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ENPP2 wt Allele

Papers overview

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2016
2016
Symposium for Young Neuroscientists and Professors of the SouthEast
Major and invasive surgeries are associated with a higher risk of developing chronic postoperative pain. We hypothesize that a… 
2015
2015
Favorable human safety, pharmacokinetics and pharmacodynamics of the autotaxin inhibitor GLPG1690, a potential new treatment in COPD
Introduction: Autotaxin (ATX) is a secreted enzyme with lysophospholipase D activity responsible for the production of the… 
Review
2015
Review
2015
The autotaxin-LPA 2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair
In this study we characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR… 
Review
2015
Review
2015
[Lysophosphatidic acid and malignant neoplasms].
Lysophosphatidic acid (LPA) is a lipid compound which plays an important role in the human body, enabling its proper development… 
2014
2014
Dihydropyrido pyrimidine compounds as autotaxin inhibitors
The present invention provides a compound or a pharmaceutically acceptable salts of formula (I). The compounds of the present… 
Review
2013
Review
2013
[Clinical introduction of lysophosphatidic acid and autotaxin assays].
The lysophospholipid mediator lysophosphatidic acid (LPA) has been shown to elicit a variety of (patho) physiological responses… 
2013
2013
Obesity and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) polymorphism and their association with pathophysiology diabetes type 2 in Central Indian population
Diabetes is a metabolic disorder characterized by hyperglycemia (excessive amount of glucose) and is associated with abnormal… 
2010
2010
Piperidine and piperazine derivatives as autotaxin inhibitor
The present invention provides a compound of formula as autotaxin inhibitor (Ia), is caused by activation of (Ib) and (II… 
2004
2004
Characterization of human melanoma cell lines according to their migratory properties in vitro
SummaryThe migratory responses of four human melanoma cell lines (A-2058, DEMEL, HTB-63, and HTB-72), using chemotaxis (CTX) and… 
1983
1983
Combined action of intraaxonal iodate and external sea anemone toxin ATX II on sodium channel inactivation of frog nerve fibres
Abstract1.Voltage clamp experiments were done on single myelinated nerve fibres of the frog,Rana esculenta, with 10 mM TEA+ in…