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Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL precursor cellsExpand
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Regulation of Oligodendrocyte Differentiation and Myelination
  • B. Emery
  • Biology, Medicine
  • Science
  • 5 November 2010
Despite the importance of myelin for the rapid conduction of action potentials, the molecular bases of oligodendrocyte differentiation and central nervous system (CNS) myelination are stillExpand
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Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulatorExpand
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LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
Multiple sclerosis (MS) is a disabling inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects young adults. Available therapies can inhibit the inflammatoryExpand
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Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System
Mechanistic studies of CNS myelination have been hindered by the lack of a rapidly myelinating culture system. Here, we describe a versatile CNS coculture method that allows time-lapse microscopy andExpand
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Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capableExpand
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Mechanisms regulating the development of oligodendrocytes and central nervous system myelin
Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization that enables rapid and efficient nerve conduction within the central nervous system. The generation of myelinExpand
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MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes
Oligodendrocyte development and myelination rely on an unusual membrane-associated transcription factor that shares functional domains with bacteriophage proteins.
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Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System.
  • B. Emery, Q. Lu
  • Medicine, Biology
  • Cold Spring Harbor perspectives in biology
  • 1 September 2015
Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly orchestrated process involving well-defined steps from specification of neural stem cells into proliferative OLExpand
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Transcriptional and post-transcriptional control of CNS myelination
  • B. Emery
  • Biology, Medicine
  • Current Opinion in Neurobiology
  • 1 October 2010
The successful transduction of action potentials along vertebrate axons is highly reliant on myelin, the concentric layers of membrane surrounding most large diameter axons. Within the centralExpand
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