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Echinomycin

Known as: Echinomycin A, Bis-Quinoline Analogue, N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide) 
A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two… 
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (13)

1QN-echinomycinNSC-526417RK-1355AUK 63052

Broader (3)

Anti-Bacterial AgentsAntibiotics, AntineoplasticNucleic Acid Synthesis Inhibitors
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
A Novel One-Pot Synthesis of Quinoxaline Derivatives in Fluorinated Alcohols
Hexafluoroisopropanol (HFIP) is explored as an effective medium for the synthesis of quinoxaline derivatives in high yields at… 
2008
2008
The effects of local DNA sequence on the interaction of ligands with their preferred binding sites.
Review
2004
Review
2004
Echinomycin: The first bifunctional intercalating agent in clinical trials
SummaryEchinomycin is a quinoxaline antibiotic that was originally isolated from Streptomyces echinatus. Based on its antitumor… 
Highly Cited
1999
Highly Cited
1999
Recognition elements that determine affinity and sequence-specific binding to DNA of 2QN, a biosynthetic bis-quinoline analogue of echinomycin.
Footprinting experiments with DNase I provide a starting-point for investigating the molecular basis of nucleotide sequence… 
Review
1989
Review
1989
Antitumour drug–DNA interactions: NMR studies of echinomycin and chromomycin complexes
  • X. GaoD. Patel
  • Quarterly Reviews of Biophysics (print)
  • 1989
  • Corpus ID: 10292702
The intelligent design of new families of DNA-binding antitumour agents must await an understanding at the molecular level of the… 
Highly Cited
1984
Highly Cited
1984
Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.
The technique of DNAase I footprinting has been used to investigate preferred binding sites for echinomycin on a 160-base-pair… 
1980
1980
Binding of quinoline analogues of echinomycin to deoxyribonucleic acid. Role of the chromophores.
Two novel antibiotics were isolated, designated compounds 1QN and 2QN respectively, having quinoline rings in place of one or… 
Highly Cited
1976
Highly Cited
1976
The binding of echinomycin to deoxyribonucleic acid.
Echinomycin is a peptide antibiotic which binds strongly to double-helical DNA up to a limit of approximately one molecule per… 
Highly Cited
1967
Highly Cited
1967
The mode of action of quinoxaline antibiotics. Interaction of quinomycin A with deoxyribonucleic acid.
Highly Cited
1966
Highly Cited
1966
Le phénomène de la ségrégation nucléolaire: Spécificité d'action de certains antimétabolites
Sous l'effet de certains composés, le nucléole présente des lésions morphologiques distinctes et caractéristiques. Ces lésions… 
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