Skip to search formSkip to main contentSkip to account menu

Echinomycin

Known as: Echinomycin A, Bis-Quinoline Analogue, N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide) 
A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two… 
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (13)

1QN-echinomycinNSC-526417RK-1355AUK 63052

Broader (3)

Anti-Bacterial AgentsAntibiotics, AntineoplasticNucleic Acid Synthesis Inhibitors
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
A Novel One-Pot Synthesis of Quinoxaline Derivatives in Fluorinated Alcohols
Hexafluoroisopropanol (HFIP) is explored as an effective medium for the synthesis of quinoxaline derivatives in high yields at… 
1985
1985
Phase I study of echinomycin administered on an intermittent bolus schedule.
We have conducted a phase I study of the cyclic peptide echinomycin (Quinomycin A) on a schedule of administration of once every… 
1984
1984
Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation.
Streptomyces echinatus A8331 cultured on a maltose minimal salts medium normally produces a single antibiotic, echinomycin… 
1984
1984
Stopped-flow kinetic studies on the interaction between echinomycin and DNA.
The kinetics of association between the quinoxaline antitumor antibiotic echinomycin and DNA have been studied by stopped-flow… 
1984
1984
Directed biosynthesis of novel derivatives of echinomycin. II. Purification and structure elucidation.
New antibiotics produced by Streptomyces echinatus A8331 cultured in the presence of heterocyclic aromatic acids can be separated… 
1983
1983
Effect of phosphate and amino acids on echinomycin biosynthesis by Streptomyces echinatus
Streptomyces echinatus produces only echinomycin (quinomycin A), in contrast to other streptomycetes, which produce families of… 
1980
1980
Binding of quinoline analogues of echinomycin to deoxyribonucleic acid. Role of the chromophores.
Two novel antibiotics were isolated, designated compounds 1QN and 2QN respectively, having quinoline rings in place of one or… 
1980
1980
Effects of counterstaining with DNA binding drugs on fluorescent banding patterns of human and mammalian chromosomes.
Pairs of fluorescent A-T specific dyes and nonfluorescent agents with similar or complementary base pair binding specificity were… 
Highly Cited
1978
Highly Cited
1978
Interaction between synthetic analogues of quinoxaline antibiotics and nucleic acids. Changes in mechanism and specificity related to structural alterations.
The interaction with DNA of six chemically synthesized derivatives of the quinoxaline antibiotics was investigated. Five of the… 
Highly Cited
1978
Highly Cited
1978
Bifunctional intercalation and sequence specificity in the binding of quinomycin and triostin antibiotics to deoxyribonucleic acid.
Quinomycin C, triostin A and triostin C are peptide antibiotics of the quinoxaline family, of which echinomycin (quinomycin A) is…