Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Echinomycin

Known as: Echinomycin A, Bis-Quinoline Analogue, N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide) 
A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Molecular targeting of cancer stem cells (CSCs) has therapeutic potential for efficient treatment of cancer, although relatively… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The identification of small molecules that inhibit the sequence-specific binding of transcription factors to DNA is an attractive… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
We used synthetic lethal high-throughput screening to interrogate 23,550 compounds for their ability to kill engineered… Expand
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Differential scanning calorimetry and UV thermal denaturation have been used to determine a complete thermodynamic profile for… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2003
Highly Cited
2003
An endophytic streptomycete (NRRL 30566) is described and partially characterized from a fern-leaved grevillea (Grevillea… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Footprinting experiments with DNase I provide a starting-point for investigating the molecular basis of nucleotide sequence… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1984
1984
The preferred binding sites of echinomycin on DNA can be determined by a method called "footprinting." A 32P end-labeled… Expand
Is this relevant?
Highly Cited
1975
Highly Cited
1975
In the light of evidence based on ’H and I3C nuclear magnetic resonance experiments, and on electron impact and field desorption… Expand
  • figure 1
  • figure 2
  • table 11
  • figure 5
  • figure 3
Is this relevant?
Highly Cited
1974
Highly Cited
1974
The interaction between echinomycin and circular DNA or sonicated rod-like DNA fragments shows that this antibiotic binds by a… Expand
Is this relevant?