Echinomycin

Known as: Echinomycin A, Bis-Quinoline Analogue, N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide) 
A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
051019532017

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Highly Cited
2011
Highly Cited
2011
Molecular targeting of cancer stem cells (CSCs) has therapeutic potential for efficient treatment of cancer, although relatively… (More)
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2007
2007
Hypoxia-inducible factor-1 (HIF-1) is now recognized as a possible target for cancer treatment. This transcription factor is… (More)
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Highly Cited
2005
Highly Cited
2005
The identification of small molecules that inhibit the sequence-specific binding of transcription factors to DNA is an attractive… (More)
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2003
2003
Differential scanning calorimetry and UV thermal denaturation have been used to determine a complete thermodynamic profile for… (More)
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Highly Cited
2003
Highly Cited
2003
We used synthetic lethal high-throughput screening to interrogate 23,550 compounds for their ability to kill engineered… (More)
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1995
1995
Echinomycin, a cyclic peptide in the family of quinoxaline antibiotics, was evaluated in patients with metastatic, soft tissue… (More)
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1987
1987
Echinomycin was administered to patients with advanced carcinoma in escalating doses ranging from 60 to 1500 micrograms/m2 given… (More)
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1986
1986
When nucleosome cores reconstituted from chicken erythrocyte histones and a 160 bp DNA molecule are exposed to echinomycin, a bis… (More)
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1984
1984
The preferred binding sites of echinomycin on DNA can be determined by a method called "footprinting." A 32P end-labeled… (More)
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1976
1976
Echinomycin is a peptide antibiotic which binds strongly to double-helical DNA up to a limit of approximately one molecule per… (More)
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