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EUK-134

Known as: EUK134 
National Institutes of Health

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2 relations

Broader (2)

Organometallic CompoundsSalicylates

Papers overview

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2018
2018
Hypertrophied myocardium is vulnerable to ischemia/reperfusion injury and refractory to rapamycin-induced protection due to increased oxidative/nitrative stress.
Left ventricular hypertrophy (LVH) is causally related to increased morbidity and mortality following acute myocardial infarction… 
2015
2015
Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts
Adenosine increases coronary flow mainly through the activation of A2A and A2B adenosine receptors (ARs). However, the mechanisms… 
2011
2011
Striatal Neuroprotection from Neonatal Hypoxia-Ischemia in Piglets by Antioxidant Treatment with EUK-134 or Edaravone
Striatal neurons are highly vulnerable to hypoxia-ischemia (HI) in term newborns. In a piglet model of HI, striatal neurons… 
2011
2011
Modulation of H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells by EUK134, a salen derivative.
Alzheimer's disease is a neurodegenerative disorder that is characterized by the accumulation of senile plaques containing… 
Highly Cited
2006
Highly Cited
2006
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS)
Overexpression of the c-Met/hepatocyte growth factor receptor(HGF-R) proto-oncogene and abnormal generation of intracellular… 
2004
2004
EUK-134 Reduces Renal Dysfunction and Injury Caused by Oxidative and Nitrosative Stress of the Kidney
Background/Aims: Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R… 
2003
2003
Nitric-oxide-induced depolarization of neuronal mitochondria: implications for neuronal cell death
2003
2003
Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria
2003
2003
Induction of apoptosis in fetal pulmonary arterial smooth muscle cells by a combined superoxide dismutase/catalase mimetic.
Reactive oxygen species (ROS) such as superoxide and hydrogen peroxide are known to play an important role in the proliferation… 
Highly Cited
2002
Highly Cited
2002
Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat.
BACKGROUND Reactive oxygen species contribute to the multiple organ failure endotoxic shock. Here we investigate the effects of a… 
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