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Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
TLDR
Developing C‐terminal, antioligopeptide antibodies that were specific for each glutamate transporter subtype found that GLT‐1 immunoreactive protein was severely decreased in ALS, both in motor cortex (71% decrease compared with control) and in spinal cord.
Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues
TLDR
Examination of the expression of PS1 and PS2 mRNA and PS1 protein in human and mouse tissues revealed that PS 1 protein accumulates in a variety of neuronal populations with enrichment in somatodendritic and neuropil compartments, and it is demonstrated that PS1 accumulates as ∼28 kDa N-terminal and ∼18 kDa C-Terminal fragments in brain.
Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation
TLDR
Motor neurons can engage epigenetic mechanisms to drive apoptosis, involving Dnmt upregulation and increased DNA methylation, and these cellular mechanisms could be relevant to human ALS pathobiology and disease treatment.
Neuronal cell death in neonatal hypoxia‐ischemia
TLDR
It is conceptualized based on morphological and biochemical data that this degeneration is better classified according to an apoptosis‐necrosis cell death continuum and that programmed cell necrosis has prominent contribution in the neurodegeneration of HIE in animal models.
Early Neurodegeneration after Hypoxia-Ischemia in Neonatal Rat Is Necrosis while Delayed Neuronal Death Is Apoptosis
TLDR
The results show that hypoxia-ischemia in the developing brain causes both early and delayed neurodegeneration in specific systems in which the morphology of neuronal death is determined by time, region, and potentially by patterns of neuronal connectivity.
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
TLDR
Mitochondria in neurons had terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling-positive matrices and p53 at the outer membrane and A53T mutant mice develop intraneuronal inclusions, mitochondrial DNA damage and degeneration, and apoptotic-like death of neocortical, brainstem, and motor neurons.
Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease
TLDR
It is concluded that synaptic abnormalities in the hippocampus correlate with the severity of neuropathology and memory deficit in individuals with AD, and that this defect may predate neuropsychological evidence for cognitive impairment early in AD.
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