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ERCC4-ERCC1 complex

Known as: Rad1-Rad10 complex location, XPF-ERCC1 complex location, XPF-ERCC1 complex 
A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
The association between the ERCC1/2 polymorphisms and the clinical outcomes of the platinum-based chemotherapy in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis
The relationship between the ERCC1/2 single nucleotide polymorphisms (SNPs) and the clinical outcomes of the platinum-based… 
2013
2013
Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination.
DNA double-strand breaks (DSB) occur frequently during replication in sister chromatids and are dramatically increased when cells… 
Review
2013
Review
2013
Polymorphisms in ERCC1 C8092A predict progression-free survival in metastatic/recurrent nasopharyngeal carcinoma treated with cisplatin-based chemotherapy
ObjectivesWe evaluated whether DNA repair gene polymorphisms had an effect on clinical outcomes in metastatic/recurrent… 
Review
2011
Review
2011
ERCC1 and ERCC2 Polymorphisms Predict Clinical Outcomes of Oxaliplatin-Based Chemotherapies in Gastric and Colorectal Cancer: A Systemic Review and Meta-analysis
Purpose: Nucleotide excision repair (NER) modulates platinum-based chemotherapeutic efficacy by removing drug-produced DNA damage… 
Highly Cited
2011
Highly Cited
2011
Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy
The aim of the study was the identification of a pharmacogenetic profile predictive of the tumor regression grade (TRG… 
Review
2011
Review
2011
A review of excision repair cross-complementation group 1 in colorectal cancer.
Highly Cited
2010
Highly Cited
2010
Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.
Review
2009
Review
2009
Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: a Korean population-based study.
Review
2005
Review
2005
ERCC1 and ERCC2 polymorphisms and adult glioma.
ERCC2 and ERCC1 are important in DNA nucleotide excision repair and lie on chromosome 19q13.3 near a putative glioma suppressor… 
Highly Cited
2004
Highly Cited
2004
Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy.
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