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ENG wt Allele

Known as: CD105 Gene, ORW Gene, Endoglin (Osler-Rendu-Weber Syndrome 1) wt Allele 
Human ENG wild-type allele is located within 9q33-q34.1 and is approximately 40 kb in length. This allele, which encodes endoglin protein, is… 
National Institutes of Health

Related topics

Related topics

9 relations
9q33-q34.1Cell Proliferation Regulatory ProcessENG geneEndoglin, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: Data from the French-Italian HHT network
Purpose: Hereditary hemorrhagic telangiectasia is an autosomal dominant disorder characterized by arteriovenous malformations… 
Highly Cited
2006
Highly Cited
2006
Genotype–phenotype correlation in hereditary hemorrhagic telangiectasia: Mutations and manifestations *
Hereditary hemorrhagic telangiectasia (HHT) is a genetically heterogeneous vascular dysplasia with multiple telangiectases and… 
Highly Cited
2003
Highly Cited
2003
Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis
CD105 and its ligand transforming growth factor β (TGFβ) are modulators of angiogenesis, which drives tumour growth and… 
Highly Cited
2002
Highly Cited
2002
Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan
Hereditary hemorrhagic telangiectasia (HHT or Rendu‐Osler‐Weber syndrome) is an autosomal dominant disorder characterized by… 
Highly Cited
2002
Highly Cited
2002
Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β Pathways*
Endoglin is a transforming growth factor-β (TGF-β) co-receptor expressed mainly on endothelial cells and involved in… 
Highly Cited
2000
Highly Cited
2000
Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.
Endoglin (CD105) is expressed on the surface of endothelial and haematopoietic cells in mammals and binds TGFbeta isoforms 1 and… 
Highly Cited
2000
Highly Cited
2000
Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer
CD105 (endoglin), a receptor for transforming growth factor (TGF) β1 and β3 in vascular endothelial cells, is highly up‐regulated… 
Highly Cited
1999
Highly Cited
1999
Defective angiogenesis in mice lacking endoglin.
Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells. Loss-of… 
Highly Cited
1996
Highly Cited
1996
Clinical heterogeneity in hereditary haemorrhagic telangiectasia: are pulmonary arteriovenous malformations more common in families linked to endoglin?
Pulmonary arteriovenous malformations (PAVMs) occur in up to 27% of patients with hereditary haemorrhagic telangiectasia (HHT… 
Review
1995
Review
1995
Medical complications of pregnancy in hereditary haemorrhagic telangiectasia.
Hereditary haemorrhagic telangiectasia (HHT) displays significant variation in severity between affected individuals in the same… 
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