Skip to search formSkip to main contentSkip to account menu

EMD 87580

Known as: EMD-87580, EMD87580 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Cardioprotective efficacy against reperfusion injury of EMD-87580: Comparison to ischemic postconditioning.
Highly Cited
2010
Highly Cited
2010
Expression of mitochondrial fusion–fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition
Studies on the role of mitochondrial fission/fusion (MFF) proteins in the heart have been initiated recently due to their… 
2008
2008
Sodium Hydrogen Exchange 1 (NHE-1) Regulates Connexin 43 Expression in Cardiomyocytes via Reverse Mode Sodium Calcium Exchange and c-Jun NH2-Terminal Kinase-Dependent Pathways
Connexin 43, the major connexin isoform in gap junctions of cardiac ventricular myocytes, undergoes changes in distribution and… 
Highly Cited
2006
Highly Cited
2006
Structural and Functional Characterization of Transmembrane Segment VII of the Na+/H+ Exchanger Isoform 1*
The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH by exchanging one intracellular H… 
Highly Cited
2006
Highly Cited
2006
Antihypertrophic Effect of Na+/H+ Exchanger Isoform 1 Inhibition Is Mediated by Reduced Mitogen-Activated Protein Kinase Activation Secondary to Improved Mitochondrial Integrity and Decreased…
Although inhibition of Na+/H+ exchanger isoform 1 (NHE-1) reduces cardiomyocyte hypertrophy, the mechanisms underlying this… 
2006
2006
NHE-1 inhibition improves cardiac mitochondrial function through regulation of mitochondrial biogenesis during postinfarction remodeling.
We have recently demonstrated that mitochondrial respiratory dysfunction and mitochondrial permeability transition pore opening… 
Highly Cited
2005
Highly Cited
2005
NHE-1-dependent intracellular sodium overload in hypertrophic hereditary cardiomyopathy: prevention by NHE-1 inhibitor.
Highly Cited
2004
Highly Cited
2004
Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition.
Sodium/hydrogen exchange (NHE) inhibitors show promise as potential therapeutic agents for the treatment of heart failure, but it… 
2004
2004
Inhibitors of the Na+/H+ Exchanger Cannot Prevent Atrial Electrical Remodeling in the Goat
Introduction: It has been suggested that blockade of the Na+/H+ exchanger (NHE1) can prevent atrial fibrillation (AF)‐induced… 
Highly Cited
2003
Highly Cited
2003
Aldosterone Increases NHE-1 Expression and Induces NHE-1-Dependent Hypertrophy in Neonatal Rat Ventricular Myocytes
Abstract—We determined the effect of 24-hour aldosterone (100 nmol/L) treatment on hypertrophic responses in rat neonatal… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)