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Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats.
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF. Expand
Electrical, contractile and structural remodeling during atrial fibrillation.
Both AF itself and the underlying heart disease are responsible for the development of the arrhythmogenic substrate, and the role of structural remodeling in the progression of AF is still unclear. Expand
High-density mapping of electrically induced atrial fibrillation in humans.
During pacing-induced AF in humans, the RA is activated by one or multiple wavelets propagating in different directions, which appears to be characterized by different numbers and dimensions of the intra-atrial reentrant circuits. Expand
Pathophysiology and Prevention of Atrial Fibrillation
Atrial fibrillation (AF) is a ubiquitous yet diverse cardiac arrhythmia whose incidence increases with age; with most forms of cardiac and some pulmonary diseases; and with a number of metabolic,Expand
Post-operative atrial fibrillation: a maze of mechanisms
The mechanistic interaction between predisposing factors and the electrophysiological mechanisms resulting in POAF and their therapeutic implications are discussed and show that POAF is ‘multi-factorial’. Expand
Structural changes of atrial myocardium due to sustained atrial fibrillation in the goat.
This goat model of AF offers a new approach to study the cascade of events leading to sustained AF and its maintenance, and leads to predominantly structural changes in the atrial myocytes similar to those seen in ventricular myocytes from chronic hibernating myocardium. Expand
Progression from paroxysmal to persistent atrial fibrillation clinical correlates and prognosis.
The HATCH score may help to identify patients who are likely to progress to sustained forms of AF in the near future, and factors known to cause atrial structural remodeling (age and underlying heart disease) were independent predictors of AF progression. Expand
Early recurrences of atrial fibrillation after electrical cardioversion: a result of fibrillation-induced electrical remodeling of the atria?
The daily distribution of recurrences of AF suggests a temporary vulnerable electrophysiologic state of the atria, possibly due to a reduction of electrical remodeling during AF. Expand
Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The "leading circle" concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical
A new model of circulating excitation in cardiac tissue was developed, based on observations in ring-shaped strips of cardiac tissue, which found that both types of circus movement tachycardia responded differently to changes in basic electrophysiological properties such as conduction velocity and refractory period. Expand