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EM 652

Known as: EM-652 
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
OBJECTIVE EM-652 is a pure antiestrogen in human breast and uterine cancer cells that also reduces bone loss and plasma lipid… Expand
Highly Cited
2003
Highly Cited
2003
Estrogen receptor (ER)alpha and -beta interact with a variety of coactivator proteins, most notably members of the steroid… Expand
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2002
2002
EM‐652 exerts pure antiestrogenic activity in the mammary gland and endometrium, while tamoxifen, the antiestrogen most widely… Expand
Review
2001
Review
2001
A new understanding of the endocrinology of menopause is that women, at menopause, are not only lacking estrogens resulting from… Expand
Review
2001
Review
2001
In order to minimize the risks of endometrial cancer and the development of resistance to antiestrogen therapy, we have… Expand
Highly Cited
2001
Highly Cited
2001
ABSTRACT Coregulators for nuclear receptors (NR) are factors that either enhance or repress their transcriptional activity. Both… Expand
Review
1999
Review
1999
Breast cancer is the most frequent cancer in women while it is the second cause of cancer death. Estrogens are well recognized to… Expand
Highly Cited
1999
Highly Cited
1999
A naturally occurring mutation at amino acid 351 (D351Y) in the human estrogen receptor (ER) can change the pharmacology of… Expand
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Highly Cited
1998
Highly Cited
1998
Estrogens act as potent mitogens in a large number of breast cancers, and the use of estrogen receptor (ER) antagonists is… Expand
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Highly Cited
1997
Highly Cited
1997
Although temporary benefits of tamoxifen therapy are observed in up to 40% of women with breast cancer, this compound, which is… Expand
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