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Acolbifene

Known as: (2S)-3-(4-Hydroxyphenyl)-4-methyl-2-(4-(2-(1-piperidinyl)ethoxy)phenyl)-2H-1-benzopyran-7-ol 
National Institutes of Health

Related topics

Related topics

4 relations
Acolbifene HydrochlorideEM 652

Narrower (1)

SCH 57068

Broader (1)

ritetronium

Papers overview

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Review
2006
Review
2006
Estrogen receptors as therapeutic targets in breast cancer.
The estrogen receptor alpha (ERalpha) has proven to be the single most important target in breast cancer over the last 30 years… 
Highly Cited
2006
Highly Cited
2006
The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen…
Purpose: We tested whether a selective estrogen receptor modulator (SERM) and a rexinoid are active for prevention and treatment… 
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2006
2006
Identification of novel proteins induced by estradiol, 4-hydroxytamoxifen and acolbifene in T47D breast cancer cells
Tamoxifen is currently used as adjuvant therapy for estrogen receptor (ER) positive breast cancer patients and as a… 
Highly Cited
2005
Highly Cited
2005
Effects of dehydroepiandrosterone, Premarin and Acolbifene on histomorphology and sex steroid receptors in the rat vagina
To assess the specific estrogenic and/or androgenic effects of a potential novel hormone replacement therapy, we have examined… 
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2005
2005
Estrogen receptor α-mediated adiposity-lowering and hypocholesterolemic actions of the selective estrogen receptor modulator acolbifene
OBJECTIVE:The selective estrogen receptor (ER) modulator (SERM) acolbifene (ACOL), a potent and pure antiestrogen in the mammary… 
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2005
2005
Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Although approved for the treatment of hormone-dependent breast cancer as well as for the prevention of breast cancer in high… 
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2005
2005
Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors Published, JLR Papers in Press, March 1, 2005. DOI 10.1194/jlr.M400448-JLR200
This study aimed to identify the mechanisms of the hypolipidemic action of the selective estrogen receptor modulator (SERM… 
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2005
2005
Synthesis and structure–activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution
EM-652 (acolbifene) analogs have been synthesized as selective estrogen receptor modulators. Substitution on the nitrogen atom of… 
2004
2004
Activity and safety of the antiestrogen EM-800, the orally active precursor of acolbifene, in tamoxifen-resistant breast cancer.
PURPOSE To determine the efficacy and safety of EM-800 (SCH-57050), the precursor of acolbifene, a new, highly potent, orally… 
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Highly Cited
2002
Highly Cited
2002
Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator.
Cardiovascular disease is the leading cause of morbidity and mortality in postmenopausal women. EM-652 (acolbifene) is a fourth… 
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