ELAVL1 wt Allele

Known as: ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) wt Allele, MelG, ELAV1 
Human ELAVL1 wild-type allele is located in the vicinity of 19p13.2 and is approximately 47 kb in length. This allele, which encodes ELAV-like… (More)
National Institutes of Health

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Ligand BindingRNA BindingTranslational Regulation

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Highly Cited
2011
Highly Cited
2011
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly… (More)
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Highly Cited
2011
Highly Cited
2011
Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.
Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but the function of most RBPs is unknown… (More)
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Highly Cited
2003
Highly Cited
2003
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
Exposure to short-wavelength UV light (UVC) strongly induces p53 expression. In human RKO colorectal carcinoma cells, this… (More)
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Highly Cited
2003
Highly Cited
2003
Role of the RNA-binding protein HuR in colon carcinogenesis
Immunohistochemical analysis of paired tumor and normal tissue specimens revealed that the expression and cytoplasmic abundance… (More)
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Highly Cited
2001
Highly Cited
2001
HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.
Tumors of the central nervous system (CNS) often have sustained expression of labile genes, including angiogenic growth factors… (More)
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Highly Cited
2000
Highly Cited
2000
HuR regulates p21 mRNA stabilization by UV light.
Expression of the cyclin-dependent kinase inhibitor p21 is highly induced by many stresses, including exposure to short… (More)
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Highly Cited
2000
Highly Cited
2000
Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo
AU-rich elements (AREs) present in the 3' untranslated regions of many protooncogene, cytokine, and lymphokine messages target… (More)
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Highly Cited
2000
Highly Cited
2000
HuR binding to cytoplasmic mRNA is perturbed by heat shock.
AU-rich elements (AREs) located in the 3' untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and… (More)
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Highly Cited
1998
Highly Cited
1998
Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs.
The messenger RNAs of many proto-oncogenes, cytokines and lymphokines are targeted for rapid degradation through AU-rich elements… (More)
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Highly Cited
1998
Highly Cited
1998
Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR.
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor whose expression is dramatically induced by hypoxia due… (More)
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