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E 64

Known as: E-64, Oxiranecarboxylic acid, 3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))- 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

AntimalarialsCysteine Proteinase InhibitorsLeucine
analogs & derivatives

Papers overview

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Highly Cited
2006
Highly Cited
2006
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Extracellular pH (pH(e)) is lower in many tumors than in the corresponding normal tissue. The significance of acidic pH(e) in the… Expand
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Highly Cited
2004
Highly Cited
2004
The demise of the marine cyanobacterium, Trichodesmium spp., via an autocatalyzed cell death pathway
We present experimental laboratory evidence and field observations of an autocatalyzed, programmed cell death (PCD) pathway in… Expand
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Highly Cited
2004
Highly Cited
2004
Conjugated Linoleic Acid Induces Human Adipocyte Delipidation
Dietary conjugated linoleic acid (CLA) reduces body fat in animals and some humans. Here we show that trans-10, cis-12 CLA, but… Expand
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Highly Cited
2000
Highly Cited
2000
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.
BACKGROUND Analysis of global changes in gene transcription and translation by systems-based genomics and proteomics approaches… Expand
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Highly Cited
1998
Highly Cited
1998
Bax cleavage is mediated by calpain during drug-induced apoptosis
The anti-apoptotic molecule Bcl-2 is located in the mitochondrial and endoplasmic reticulum membranes as well as the nuclear… Expand
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Highly Cited
1996
Highly Cited
1996
Proteolytic Activity of Human Osteoclast Cathepsin K
Human cathepsin K is a recently identified protein with high primary sequence homology to members of the papain cysteine protease… Expand
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Highly Cited
1991
Highly Cited
1991
Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).
Action of purified human cathepsin B on recombinant single-chain urokinase-type plasminogen activator (pro-uPA) generated… Expand
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Highly Cited
1990
Highly Cited
1990
PHOTOOXIDATIVE DAMAGE TO LYSOSOMES OF CULTURED MACROPHAGES BY ACRIDINE ORANGE
Abstract— Cultured cells accumulate acridine orange (AO), which is a weak basic dye and a photosensi‐tizer, in lysosomes and… Expand
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Highly Cited
1983
Highly Cited
1983
Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum.
The protein from chicken egg white that inhibits cysteine proteinases, and has been named 'cystatin', was purified by ovomucin… Expand
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Highly Cited
1982
Highly Cited
1982
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.
1. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) at a concentration of 0.5 mM had no effect on the serine… Expand
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