E 64

Known as: E-64, Oxiranecarboxylic acid, 3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbonyl)-3-methylbutyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))- 
 
National Institutes of Health

Related topics

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4 relations

Broader (3)

AntimalarialsCysteine Proteinase InhibitorsLeucine
analogs & derivatives

Papers overview

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Highly Cited
2009
Highly Cited
2009
Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2.
Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and triggers dendritic cell-mediated Th2-type inflammation… (More)
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2008
2008
Factors Contributing to the Biofilm-Deficient Phenotype of Staphylococcus aureus sarA Mutants
Mutation of sarA in Staphylococcus aureus results in a reduced capacity to form a biofilm, but the mechanistic basis for this… (More)
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Highly Cited
2006
Highly Cited
2006
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Extracellular pH (pH(e)) is lower in many tumors than in the corresponding normal tissue. The significance of acidic pH(e) in the… (More)
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Highly Cited
2005
Highly Cited
2005
Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.
We examined the mechanism of action and compared the anthelmintic efficacy of cysteine proteinases from papaya, pineapple, fig… (More)
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Highly Cited
2004
Highly Cited
2004
Papain protects papaya trees from herbivorous insects: role of cysteine proteases in latex.
Many plants contain latex that exudes when leaves are damaged, and a number of proteins and enzymes have been found in it. The… (More)
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Highly Cited
1999
Highly Cited
1999
The Cysteine Protease Activity of the Major Dust Mite Allergen Der P 1 Selectively Enhances the Immunoglobulin E Antibody Response
The house dust mite Dermatophagoides pteronyssinus allergen Der p 1 is the most immunodominant allergen involved in the… (More)
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Highly Cited
1998
Highly Cited
1998
Bax cleavage is mediated by calpain during drug-induced apoptosis
The anti-apoptotic molecule Bcl-2 is located in the mitochondrial and endoplasmic reticulum membranes as well as the nuclear… (More)
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Highly Cited
1997
Highly Cited
1997
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.
Perforin is a secreted protein synthesized by activated cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. It is a key… (More)
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1985
1985
The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64.
Using morphometric methods the effects of the thiol-proteinase inhibitors leupeptin and E-64 on the digestion of intracytoplasmic… (More)
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Highly Cited
1982
Highly Cited
1982
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.
1. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) at a concentration of 0.5 mM had no effect on the serine… (More)
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