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Drug Interactions

Known as: Interaction, Drug, INTERACTION DRUG (NOS), DRUG INTERACTION (NOS) 
A change in the way a drug acts in the body when taken with certain other drugs, herbals, or foods, or when taken with certain medical conditions… 
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (5)

Adverse drug interactionDrug PotentiationDrug SynergismFood-Drug Interactions
Adverse reaction to drugDrug KineticsMetabolic Detoxication, Phase IMetabolism

Broader (3)

Pharmacodynamicspharmacology and toxicologyphysical chemical interaction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
In Vitro Evaluation of Hepatic Transporter-Mediated Clinical Drug-Drug Interactions: Hepatocyte Model Optimization and Retrospective Investigation
To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a model to characterize transport kinetics for… 
Highly Cited
2010
Highly Cited
2010
A microfluidic chip with poly(ethylene glycol) hydrogel microarray on nanoporous alumina membrane for cell patterning and drug testing
Highly Cited
2008
Highly Cited
2008
Potential drug interactions prevalence in intensive care units.
OBJECTIVES Drug interactions occur when effects and/or toxicity of a drug are affected by presence of another drug. They are… 
Highly Cited
2007
Highly Cited
2007
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
Review
2007
Review
2007
Pharmacokinetic Drug‐Drug Interaction Potentials for Therapeutic Monoclonal Antibodies: Reality Check
A formal assessment of the drug‐drug interaction potential of any investigational drug product often requires multiple metabolic… 
Review
2006
Review
2006
Multidrug transporters as drug targets.
Transport molecules can significantly affect the pharmacodynamics and pharmacokinetics of drugs. An important transport molecule… 
Highly Cited
2004
Highly Cited
2004
Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus…
The effects of hepatic uptake and efflux transporters on metabolism of digoxin were examined in isolated rat hepatocytes versus… 
Review
2002
Review
2002
Evaluation of drug interactions with P-glycoprotein in drug discovery: in vitro assessment of the potential for drug-drug interactions with P-glycoprotein.
The pharmacological effects of a drug are highly dependent on the absorption, metabolism, elimination, and distribution of the… 
Review
2001
Review
2001
Proton pump inhibitors and their drug interactions: an evidence-based approach.
The proton pump inhibitors (PPIs) are the most effective antisecretory agents used to treat acid-related disorders. As such, they… 
Review
1989
Review
1989
Drug interactions with quinolones.
Numerous drug interactions with the new 4-quinolone antimicrobial agents have now been established. Many, but not all, quinolones… 
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