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Doxercalciferol

Known as: 1-alpha-hydroxyvitamin D2, 1?-Hydroxyergocalciferol, 1 alpha-hydroxyergocalciferol 
A synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (3)

Bone Density Conservation AgentsErgocalciferolsVitamins
Decreased Renal Ca++ Excretion [PE]Drug toxicityHypercalcemiaHyperparathyroidism

Narrower (1)

Hectorol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo.
Effects of 1.28 nmol/kg doxercalciferol [1α(OH)D₂], a synthetic vitamin D₂ analog that undergoes metabolic activation to 1α,25… 
Highly Cited
2010
Highly Cited
2010
Vitamin D insufficiency is prevalent among pregnant African American adolescents.
2008
2008
Phase II study of doxercalciferol for the treatment of myelodysplastic syndrome
We conducted a phase II trial of doxercalciferol, a vitamin D2 analogue, in 15 patients with MDS. Each received doxercalciferol… 
2005
2005
Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d…
We reported that (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647) antagonizes vitamin D receptor (VDR… 
2004
2004
Effectiveness of 1alpha-hydroxyvitamin D2 in inhibiting tumor growth in a murine transgenic pigmented ocular tumor model.
OBJECTIVE To study the effectiveness of the vitamin D analogue 1alpha-hydroxyvitamin D(2) (1alpha-OH-D(2)) in inhibiting ocular… 
2003
2003
Dramatic enhancement of antagonistic activity on vitamin D receptor: a double functionalization of 1alpha-hydroxyvitamin D3 26,23-lactones.
The synthesis of novel vitamin D receptor antagonists, 24-methyl-1alpha-hydroxyvitamin D(3) 26,23-lactones, is reported. We found… 
2002
2002
Toxicity and dose-response studies of 1alpha-hydroxyvitamin D2 in a retinoblastoma xenograft model.
BACKGROUND Although calcitriol (1,25-dihydroxycholecalciferol) and vitamin D(2) inhibit retinoblastoma growth in the athymic… 
1995
1995
Metabolism of 1 alpha-hydroxyvitamin D2 to activated dihydroxyvitamin D 2 metabolites decreases endogenous 1 alpha, 25-dihydroxyvitamin D 3 in rats and monkeys.
The vitamin D analog 1 alpha-hydroxyvitamin D2 (1 alpha-OHD2) is under development for the treatment of secondary… 
1982
1982
Observations on the dietary practices of Asians in the United Kingdom.
The efficacy of a health education campaign to improve the vitamin D status of Asians has been assessed. The average daily… 
1978
1978
Direct C-1 hydroxylation of vitamin D compounds: convenient preparation of 1alpha-hydroxyvitamin D3, 1alpha, 25-dihydroxyvitamin D3, and 1alpha-hydroxyvitamin D2.
An efficient procedure for the direct C-1 hydroxylation of vitamin D compounds has been developed. The method involves conversion… 
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