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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
The isolation of a complementary DNA segment that detects a chromosomal segment having the properties of the gene at this locus is described, which is expressed in many tumour types, but no RNA transcript has been found in retinoblastomas and osteosarcomas. Expand
Characteristics of an established cell line of retinoblastoma.
Cooperative tumorigenic effects of germline mutations in Rb and p53
- B. Williams, L. Remington, D. Albert, S. Mukai, R. Bronson, T. Jacks
- Biology, Medicine
- Nature Genetics
- 1 August 1994
The phenotypic effects of combined germline mutations in these two tumour suppressor genes Rb and p53 are described to indicate that mutations in Rband p53 can cooperate in the transformation of certain cell types in the mouse. Expand
Epidemiologic aspects of uveal melanoma.
This paper evaluates the available evidence for sunlight and other potential risk factors for uveal melanoma, highlighting areas requiring further research. Expand
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
- K. Howes, N. Ransom, D. Papermaster, J. Lasudry, D. Albert, J. Windle
- Biology, Medicine
- Genes & development
- 1 June 1994
The role of p53 in the development of retinoblastoma in mice was addressed and p53 is required for the induction of apoptosis in this model, because mice expressing E7 in a p53 nullizygous background develop retinal tumors instead of undergoing retinal degeneration. Expand
Prostaglandin-induced hair growth.
The increased number of visible lashes is consistent with the ability of latanoprost to induce anagen (the growth phase) in telogen (resting) follicles while inducing hypertrophic changes in the involved follicles. Expand
Principles and practice of ophthalmology
Providing the most comprehensive and convenient way to reference all of the latest developments in Opthamology, this CD-Rom allows users to search all six volumes with a single query. Expand
Retinoblastoma in transgenic mice
It is reported that expression of a viral oncogene, the simian virus 40 T antigen, in the retina of transgenic mice produces heritable ocular tumours with histological, ultrastructural and immunohis-tochemical features identical to those of human retinoblastoma. Expand
A historical review of sympathetic ophthalmia and its epidemiology.
The etiology of the disease remains elusive, although the pathogenesis appears to be due to delayed hypersensitivity (cell-mediated immunity), possibly directed at a surface membrane antigen that is shared by photoreceptors, retinal pigment epithelium and choroidal melanocytes. Expand
Ocular tuberculosis is an extrapulmonary mycobacterial infection with variable manifestations and it is imperative for physicians to consider this diagnosis in their differential, as ocular tuberculosis can present in a fashion similar to that of more common conditions causing ocular inflammation. Expand