Skip to search formSkip to main contentSkip to account menu

Dolasetron

Known as: octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate, indole-3-carboxylic acid, ester with (8R)-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one, Dolasétron 
An indole derivative and a potent serotonin 5-HT3 receptor antagonist with anti-emetic property. Dolasetron blocks the activity of serotonin released… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (4)

AntiemeticsIndolesQuinolizinesSerotonin Antagonists
Dolasetron 50 MG Oral Tablet [Anzemet]Drug AllergyNauseaSerotonin 3 Receptor Antagonists [MoA]

Narrower (2)

MDL 73,147EFdolasetron mesylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Large-conductance K+ channel opener CGS7184 as a regulator of endothelial cell function.
2005
2005
Dolasetron and peri‐operative cardiac arrhythmia
in Fig. 3 follow appropriately conducted p waves; hence this is not complete heart block. Ephedrine was administered in boluses… 
2003
2003
Dolasetron for the prevention of postoperative vomiting in children undergoing strabismus surgery
Background: Children undergoing strabismus surgery have a high incidence of postoperative vomiting (POV). The purpose of this… 
2003
2003
Patient outcomes after therapeutic interchange of dolasetron for granisetron.
The impact of using therapeutic interchange (TI) of dolasetron for granisetron for the prevention of chemotherapy-induced nausea… 
2002
2002
[Dolasetron reduces pain on injection of propofol].
OBJECTIVE Pain on injection is a well known side-effect of propofol. The present study was designed to assess the efficacy of… 
1997
1997
Prevention of acute emesis in cancer patients following high-dose cisplatin with the combination of oral dolasetron and dexamethasone.
PURPOSE Dolasetron is a 5-HT3 antagonist antiemetic with active oral and intravenous formulations. The effects of this class are… 
1997
1997
A double-blind, randomized study of two different dosage regimens of intravenous dolasetron in patients receiving high-dose cisplatin chemotherapy.
This study compared the antiemetic efficacy and safety of two different intravenous (i.v.) dolasetron dosing regimens in patients… 
1996
1996
Use of electrospray ionization liquid chromatography-mass spectrometry to study the role of CYP2D6 in the in vitro metabolism of 5-hydroxytryptamine receptor antagonists.
1996
1996
Dose-ranging evaluation of the antiemetic efficacy of intravenous dolasetron in patients receiving chemotherapy with doxorubicin or cyclophosphamide
Selective 5-HT3 antagonists have proven to be safe and effective for the prevention of chemotherapy-induced nausea and vomiting… 
1995
1995
Stereoselectivity of the carbonyl reduction of dolasetron in rats, dogs, and humans.
The initial step in the metabolism of dolasetron or MDL 73,147EF [(2 alpha, 6 alpha, 8 alpha, 9a beta)-octahydro-3-oxo-2,6… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)