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Dolasetron

Known as: octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate, indole-3-carboxylic acid, ester with (8R)-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one, Dolasétron 
An indole derivative and a potent serotonin 5-HT3 receptor antagonist with anti-emetic property. Dolasetron blocks the activity of serotonin released… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Pain, nausea and vomiting are frequently listed by patients as their most important perioperative concerns. With the change in… Expand
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Highly Cited
2009
Highly Cited
2009
Part I of this article discussed the potential functional importance of genetic mutations and alleles of the human cytochrome… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Palonosetron is a second-generation 5-hydroxytryptamine 3 (5-HT(3))-receptor antagonist that has shown better efficacy… Expand
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Highly Cited
2003
Highly Cited
2003
Palonosetron, a highly selective and potent 5‐HT3 receptor antagonist with a strong binding affinity and a long plasma… Expand
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2003
2003
The present study was conducted to determine the effects of two potent 5-HT4 receptor agonists, BIMU 1 (1 (3-ethyl-2,3-dihydro-N… Expand
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1996
1996
The 5-HT (5-hydroxytryptamine)-induced contractile biphasic concentration-effect curve in rat isolated jejunum was investigated… Expand
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Highly Cited
1993
Highly Cited
1993
In the rabbit isolated perfused hear, dolasetron (MDL 73,147) was found to be a potent (PA2 = 9.8) antagonist at 5… Expand
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Highly Cited
1992
Highly Cited
1992
1. Whole-cell and single-channel voltage-clamp techniques were used to record the 5-HT3 receptor-mediated currents in neurons… Expand
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Highly Cited
1991
Highly Cited
1991
We have previously reported that serotonin (5-hydroxytryptamine [5HT]) alters cultured bovine pulmonary artery smooth muscle cell… Expand
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Highly Cited
1990
Highly Cited
1990
The selective 5-HT3 receptor agonist 2-methyl-serotonin (2-Me-5-HT) mimicked the antinociceptive activity of 5-HT when… Expand
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