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Dolasetron

Known as: octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate, indole-3-carboxylic acid, ester with (8R)-hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one, Dolasétron 
An indole derivative and a potent serotonin 5-HT3 receptor antagonist with anti-emetic property. Dolasetron blocks the activity of serotonin released… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (4)

AntiemeticsIndolesQuinolizinesSerotonin Antagonists
Dolasetron 50 MG Oral Tablet [Anzemet]Drug AllergyNauseaSerotonin 3 Receptor Antagonists [MoA]

Narrower (2)

MDL 73,147EFdolasetron mesylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Serotonin type 3-receptor antagonists for chemotherapy-induced nausea and vomiting: therapeutically equivalent or meaningfully different?
Before the introduction of serotonin type 3–receptor (5-HT3) antagonists, nausea and vomiting were the most frequently reported… 
Review
2006
Review
2006
Pharmacological prophylaxis and management of adult postoperative/postdischarge nausea and vomiting.
2002
2002
RETRACTED ARTICLE: Dolasetron, but not metoclopramide prevents nausea and vomiting in patients undergoing laparoscopic cholecystectomy
PURPOSE Postoperative nausea and vomiting (PONV) is one of the most frequent complications of general anesthesia. The aim of the… 
2002
2002
[Dolasetron reduces pain on injection of propofol].
OBJECTIVE Pain on injection is a well known side-effect of propofol. The present study was designed to assess the efficacy of… 
Review
2000
Review
2000
5-HT3 receptor antagonistsvs traditional agents for the prophylaxis of postoperative nausea and vomiting
Purpose: Numerous antiemetics have been studied for the prevention of postoperative nausea and vomiting (PONV) including… 
Review
1997
Review
1997
5-HT3 receptor antagonists: differences and similarities.
1997
1997
Prevention of acute emesis in cancer patients following high-dose cisplatin with the combination of oral dolasetron and dexamethasone.
PURPOSE Dolasetron is a 5-HT3 antagonist antiemetic with active oral and intravenous formulations. The effects of this class are… 
1997
1997
Effect of ramosetron on short-circuit current response in rat colonic mucosa.
1996
1996
Use of electrospray ionization liquid chromatography-mass spectrometry to study the role of CYP2D6 in the in vitro metabolism of 5-hydroxytryptamine receptor antagonists.
1995
1995
Stereoselectivity of the carbonyl reduction of dolasetron in rats, dogs, and humans.
The initial step in the metabolism of dolasetron or MDL 73,147EF [(2 alpha, 6 alpha, 8 alpha, 9a beta)-octahydro-3-oxo-2,6… 
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