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Diquafosol

Known as: diuridine 5'-(pentahydrogen tetraphosphate) tetrasodium salt 
National Institutes of Health

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Diquafosol Tetrasodium

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PolyphosphatesUracil Nucleotides

Papers overview

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Review
2019
Review
2019
Efficacy of topical ophthalmic drugs in the treatment of dry eye disease: A systematic literature review.
2018
2018
Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model.
Purpose To evaluate the effect of diquafosol on corneal epithelium in a dry eye model using Transwell culture and a scopolamine… 
Review
2017
Review
2017
Purinergic Signalling: Therapeutic Developments
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this… 
Review
2017
Review
2017
Relevance of Lipid-Based Products in the Management of Dry Eye Disease
Abstract Components of the ocular surface synergistically contribute to maintaining and protecting a smooth refractive layer to… 
2015
2015
A randomised, parallel-group comparison study of diquafosol ophthalmic solution in patients with dry eye in China and Singapore
Aims To compare the efficacy and safety of 3% diquafosol ophthalmic solution with those of 0.1% sodium hyaluronate ophthalmic… 
Highly Cited
2013
Highly Cited
2013
Topical diquafosol for patients with obstructive meibomian gland dysfunction
Aims To evaluate the effect of topical diquafosol in patients with meibomian gland dysfunction (MGD) using tear film parameters… 
Highly Cited
2012
Highly Cited
2012
A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients
Aims To compare the efficacy and safety of 3% diquafosol ophthalmic solution with those of 0.1% sodium hyaluronate ophthalmic… 
Highly Cited
2012
Highly Cited
2012
Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial.
Review
2006
Review
2006
P2 receptors activated by uracil nucleotides--an update.
Pyrimidine nucleotides, including UTP, UDP and UDP-glucose, are important signaling molecules which activate G protein-coupled… 
Highly Cited
2004
Highly Cited
2004
Diquafosol Elicits Increases in Net Cl– Transport through P2Y2 Receptor Stimulation in Rabbit Conjunctiva
The purpose of the present study was to understand the mechanisms of action of diquafosol, a stable derivative of uridine 5… 
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