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Dimethylallyltranstransferase

Known as: Synthetase, Geranylpyrophosphate, Geranylpyrophosphate Synthetase, Synthetase, Nerylpyrophosphate 
An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (2)

4-hydroxybenzoic acid oligoprenyltransferase, E coliRER2 protein, S cerevisiae
FDPS geneGeranylgeranyl Pyrophosphate SynthetaseGeranyltranstransferaseIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis
Ubiquinone (also known as coenzyme Q) is a ubiquitous lipid-soluble redox cofactor that is an essential component of electron… 
Highly Cited
2009
Highly Cited
2009
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria
Ergot alkaloids are toxins and important pharmaceuticals that are produced biotechnologically on an industrial scale. The first… 
Highly Cited
2007
Highly Cited
2007
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi
Fusicoccins are a class of diterpene glucosides produced by the plant-pathogenic fungus Phomopsis amygdali. As modulators of 14-3… 
Highly Cited
2004
Highly Cited
2004
Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase.
The lyngbyatoxins are potent skin irritants produced by Lyngbya majuscula and cause a condition known as "Swimmer's Itch" off… 
Review
2002
Review
2002
Structure, mechanism and function of prenyltransferases.
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate… 
Highly Cited
1999
Highly Cited
1999
Geranyl diphosphate synthase: cloning, expression, and characterization of this prenyltransferase as a heterodimer.
Geranyl diphosphate synthase, which catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to… 
Highly Cited
1998
Highly Cited
1998
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
The influence of activated ras oncogenes on the sensitivity of human tumor cells to killing by radiation has been an unresolved… 
Highly Cited
1994
Highly Cited
1994
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.
The synthesis of farnesyl diphosphate (FPP), a key intermediate in the isoprenoid biosynthetic pathway required for the synthesis… 
Highly Cited
1994
Highly Cited
1994
Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II.
Prenyltransferases that catalyze the fundamental chain elongation reaction in the isoprenoid biosynthetic pathway contain several… 
Highly Cited
1990
Highly Cited
1990
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein.
The post-translational processing of the yeast a-mating pheromone precursor, Ras proteins, nuclear lamins, and some subunits of… 
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