Dimethylallyltranstransferase

Known as: Synthetase, Geranylpyrophosphate, Geranylpyrophosphate Synthetase, Synthetase, Nerylpyrophosphate 
An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to… (More)
National Institutes of Health

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4-hydroxybenzoic acid oligoprenyltransferase, E coliRER2 protein, S cerevisiae
FDPS geneGeranylgeranyl Pyrophosphate SynthetaseGeranyltranstransferaseIn Blood
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Papers overview

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Review
2009
Review
2009
Prenyl transfer to aromatic substrates: genetics and enzymology.
Aromatic prenyltransferases catalyze the transfer of prenyl moieties to aromatic acceptor molecules and give rise to an… (More)
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Highly Cited
2008
Highly Cited
2008
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
Rho GTPases (20 human members) comprise a major branch of the Ras superfamily of small GTPases, and aberrant Rho GTPase function… (More)
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Review
2004
Review
2004
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Xanthohumol (3'-[3,3-dimethyl allyl]-2',4',4-trihydroxy-6'-methoxychalcone) is the principal prenylated flavonoid of the female… (More)
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Highly Cited
2003
Highly Cited
2003
Molecular cloning, expression and characterization of cDNA encoding cis-prenyltransferases from Hevea brasiliensis. A key factor participating in natural rubber biosynthesis.
Natural rubber from Hevea brasiliensis is a high molecular mass polymer of isoprene units with cis-configuration. The enzyme… (More)
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Highly Cited
1999
Highly Cited
1999
Geranyl diphosphate synthase: cloning, expression, and characterization of this prenyltransferase as a heterodimer.
Geranyl diphosphate synthase, which catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to… (More)
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Highly Cited
1998
Highly Cited
1998
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
The influence of activated ras oncogenes on the sensitivity of human tumor cells to killing by radiation has been an unresolved… (More)
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1998
1998
Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyltransferase in cells induced for taxol…
Geranylgeranyl diphosphate synthase supplies the essential acyclic precursor for Taxol biosynthesis in methyl jasmonate-induced… (More)
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Highly Cited
1994
Highly Cited
1994
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.
The synthesis of farnesyl diphosphate (FPP), a key intermediate in the isoprenoid biosynthetic pathway required for the synthesis… (More)
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Highly Cited
1989
Highly Cited
1989
Rubber elongation factor from Hevea brasiliensis. Identification, characterization, and role in rubber biosynthesis.
The presence of a protein, rubber elongation factor (REF), which is tightly bound to serum-free rubber particles purified from… (More)
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Highly Cited
1984
Highly Cited
1984
T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin biosynthesis.
Phytohormone overproduction in crown gall tumors is due to the expression of several T-DNA genes. The data strongly suggest that… (More)
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