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Activated RAS promotes dimerization of members of the RAF kinase family. ATP-competitive RAF inhibitors activate ERK signalling… Expand The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric entities has been unsettled by the emerging… Expand The EGF receptor mediates many cellular responses in normal biological processes and in pathological states. Recent structural… Expand The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1… Expand Expression of the pro‐apoptotic molecule BAX has been shown to induce cell death. While BAX forms both homo‐ and heterodimers… Expand One of the assumptions of the mobile receptor hypothesis as it relates to G protein-coupled receptors is that the stoichiometry… Expand Introduction Cell growth, differentiation, migration, and apoptosis are in part regulated by polypeptide growth factors or… Expand A family of Bcl-2-related proteins regulates cell death and shares highly conserved BH1 and BH2 domains. BH1 and BH2 domains of… Expand Stat91 (a 91 kd protein that acts as a signal transducer and activator of transcription) is inactive in the cytoplasm of… Expand Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin… Expand