Dilevalol

OBJECTIVES The multidrug transporter P-glycoprotein (P-gp) appears to play a significant role in drug absorption and disposition… Expand

Essential hypertension is--at least in many subjects--associated with a decrease in insulin sensitivity, while glycaemic control… Expand

Essential hypertension is, at least in many subjects, associated with a decrease in insulin sensitivity, whereas glycemic control… Expand

1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its… Expand

1. This study investigated the influence of age on the pharmacokinetics, pharmacodynamics, general tolerability and concentration… Expand

Summary: Sixty-one patients (41 men, 20 women) aged 29-73 years, with moderate to severe hypertension, were enrolled in a… Expand

Cats anesthetized with alpha chloralose received saline or dilevalol (1 mg/kg, IV) during a 10‐minute infusion. Fifteen minutes… Expand

We compared dilevalol (an isomer of labetalol), 200-400 mg daily, against atenolol, 50-100 mg daily, in a double-blind, crossover… Expand

Dilevalol combines a nonselective blocking action on beta-receptors with selective beta 2-agonist activity. In this double-blind… Expand

The bioavailability and pharmacokinetics of dilevalol following oral and intravenous administration were investigated in 12… Expand