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A species difference in the presystemic metabolism of carbazeran in dog and man.
TLDR
The lack of detectable pharmacological effect in man following oral administration of the carbazeran appears to be due to presystemic metabolism by a particularly active pathway not found in the dog.
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Clinical Pharmacokinetics of Amlodipine
TLDR
Although structurally related to other dihydropyridine derivatives, amlodipine displays significantly different pharmacokinetic characteristics and is suitable for administration in a single daily dose.
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ACE (I/D) genotype as a predictor of the magnitude and duration of the response to an ACE inhibitor drug (enalaprilat) in humans.
TLDR
The effect of enalaprilat was significantly greater and lasted longer in normotensive men homozygous for the II ACE genotype and plasma angiotensin II levels were predictive of >50% of the variation in response to ACE inhibition.
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Inhibitory effect of uraemia on the hepatic clearance and metabolism of nicardipine.
TLDR
The results of this study indicate that renal impairment may have a significant and potentially important impact on the disposition of a drug which, under normal circumstances, is highly extracted by the liver.
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Effects of prostaglandins, theophylline, and cholera exotoxin upon transmucosal water and electrolyte movement in the canine jejunum.
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Doxazosin, an alpha 1-adrenoceptor antagonist: pharmacokinetics and concentration-effect relationships in man.
TLDR
Using a pharmacodynamic modelling technique in individual subjects, it was possible to show a significant correlation between the pressor responsiveness to the alpha 1-adrenoceptor agonist phenylephrine and the concentration of doxazosin in the effect compartment and its hypotensive effect.
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Enalapril Clinical Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships
TLDR
Improvements in the characterisation of concentration-time profiles for single-dose administration and the translation to steady-state have further importance for the accurate integration of the pharmacokinetic and pharmacodynamic responses to enalapril(at) in a concentration-effect model.
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White-coat hypertension as a cause of cardiovascular dysfunction
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A pharmacodynamic and pharmacokinetic assessment of a new alpha-adrenoceptor antagonist, doxazosin (UK33274) in normotensive subjects.
TLDR
The intravenous administration of doxazosin to six healthy normotensive subjects resulted in significant fall in erect blood pressure, with a corresponding increase in heart rate, but there were no significant changes in supine blood pressure or heart rate.
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How reproducible is bilateral forearm plethysmography?
TLDR
FBF ratios are more reproducible than unilateral FBF measurements at rest (CV 19% vs 39%) and for measuring responses to intra-arterial infusions of vasoconstrictor substances.
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