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Single and Multiple Dose Pharmacokinetic Evaluation of Flutamide in Normal Geriatric Volunteers
Single dose and steady‐state pharmacokinetics of flutamide (F) and its active plasma metabolite, hydroxyflutamide (HF) were studied in twelve healthy geriatric volunteers administered 250 mgExpand
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Pharmacokinetics of interferon alpha-2b in healthy volunteers.
In a three-way crossover design, 12 healthy male volunteers received 5 X 10(6) IU/m2 body surface area interferon alpha-2b(IFN alpha-2b) by intravenous (IV) infusion over 30 minutes, intramuscularExpand
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Plasma binding of betamethasone-3H, dexamethasone-3H, and cortisol-14C--a comparative study.
Abstract The binding of betamethasone (16β-methyl-9α-fluoroprednisolone) and dexamethasone (16α-methyl-9α-fluoroprednisolone) to the proteins of cow, dog, rat and human plasma has been studied inExpand
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Disposition and metabolic fate of 14C-quazepam in man.
The absorption, metabolism, and excretion of quazepam, a new benzodiazepine hypnotic, was investigated in six normal male volunteers after oral administration of 25 mg 14C-quazepam in solution.Expand
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Interspecies pharmacokinetic scaling of Sch 34343.
Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinentExpand
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Metabolism of chlorpheniramine maleate in man.
The pharmacokinetics and metabolism of 3 H-chlorpheniramine maleate have been studied in man. After a p.o. dose (12 mg), 3 H appeared rapidly in plasma and at two hours was equivalent to 32.48 mµg ofExpand
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Pharmacokinetics and Dose Proportionality of Loratadine
The dose proportionality and pharmacokinetics of loratadine, a new nonsedating antihistamine, were studied in 12 normal volunteers. In a three‐way cross‐over, each volunteer received a single 10‐,Expand
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Pharmacokinetics of Interferon α‐2b in Healthy Volunteers
In a three‐way crossover design, 12 healthy male volunteers received 5 × 106 IU/m2 body surface area interferon α‐2b(IFN α‐2b) by intravenous (IV) infusion over 30 minutes, intramuscular (IM)Expand
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Comparison of netilmicin and gentamicin pharmacokinetics in humans.
In a crossover study, single doses of netilmicin and gentamicin were administered intramuscularly, each at 1.0 and 2.5 mg/kg. The serum concentrations, analyzed by a two-compartment open model with aExpand
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Pharmacokinetics and metabolism of rosaramicin in humans.
The pharmacokinetics of rosaramicin was studied in subjects receiving 500 mg of the drug (i) by 1-h intravenous infusion, (ii) in solution orally, or (iii) as tablets orally. After intravenousExpand
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