Dihydrouracil dehydrogenase (NAD+)

Known as: Dehydrogenase, Dihydrouracil, Dihydrothymine Dehydrogenase (NAD), Dihydrouracil Dehydrogenase (NAD) 
An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This enzyme also plays a role in the catabolism of the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1957-2012
02419572012

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2006
2006
Mouse lymphoma L5178Ytk+/- (MOLY) cells and human lymphoblastoid TK6 and WTK-1 cells are widely used to detect mutagens in vitro… (More)
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1999
1999
DPD (also known as dihydrouracil dehydrogenase, dihydrothymine dehydrogenase, and uracil reductase; EC 1.3.1.2) is the initial… (More)
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Highly Cited
1996
Highly Cited
1996
We have focused our attention on the development of a novel form of a tegafur-based [FT; a prodrug of 5-fluorouracil (5-FU… (More)
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1996
1996
A potentially useful method for imaging of micrometastases and in situ radiotherapy, would be the incorporation of radioactive… (More)
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1993
1993
5-Benzylbarbituric acid derivatives were synthesized as a series of new, specific, and potent inhibitors of uridine phosphorylase… (More)
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Highly Cited
1987
Highly Cited
1987
The inhibitory effects of about 30 compounds, mainly pyrimidine and pyridine derivatives, on 5-fluorouracil degradation catalyzed… (More)
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Highly Cited
1986
Highly Cited
1986
Dihydrouracil dehydrogenase activity, with 5-fluorouracil used as the substrate, was measured in human tissues and leukemic cells… (More)
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Highly Cited
1985
Highly Cited
1985
Enzymes of the pyrimidine base catabolism, dihydrouracil dehydrogenase (EC 1.3.1.2), dihydropyrimidinase (EC 3.5.2.2), and beta… (More)
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1979
1979
A two-year-old boy with a malignant tumor of the brain (medulloblastoma) excreted large amounts of thymine and uracil in his… (More)
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1960
1960
 
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