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Dihydroorotate Dehydrogenase (Quinone), Mitochondrial, human

Known as: Dihydroorotate Dehydrogenase (Quinone), Mitochondrial, DHOdehase, EC 1.3.3.1 
Dihydroorotate dehydrogenase (quinone), mitochondrial (395 aa, ~43 kDa) is encoded by the human DHODH gene. This protein plays a role in the… 
National Institutes of Health

Related topics

Related topics

10 relations
AnabolismDHODH geneEnzyme GeneInner mitochondrial membrane

Broader (2)

Dihydroorotate OxidaseDihydroorotate dehydrogenase

Papers overview

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Highly Cited
2016
Highly Cited
2016
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, which… 
2016
2016
Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum
Plasmodium parasites are responsible for the devastating disease malaria that affects hundreds of millions of people each year… 
Highly Cited
2013
Highly Cited
2013
Anticancer Properties of Distinct Antimalarial Drug Classes
We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a… 
Highly Cited
2012
Highly Cited
2012
Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction
Some mutations of the DHODH (dihydro-orotate dehydrogenase) gene lead to postaxial acrofacial dysostosis or Miller syndrome. Only… 
Highly Cited
2012
Highly Cited
2012
Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.
Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo… 
Highly Cited
2005
Highly Cited
2005
Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase.
Highly Cited
2000
Highly Cited
2000
Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase.
In animals, dihydroorotate dehydrogenase (DHODH) is a mitochondrial protein that carries out the fourth step in de novo… 
1998
1998
Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
Mitochondrially bound dihydroorotate-ubiquinone oxidoreductase (dihydroorotate dehydrogenase, EC 1.3.99.11) catalyzes the fourth… 
Highly Cited
1995
Highly Cited
1995
Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite.
1971
1971
Pyrimidine synthesis pathway enzymes and orotic acid in bovine mammary tissue.
Abstract Studies were initiated to determine if the high orotic acid in bovine (ruminant) milk is indicative of a pathway of… 
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