DHODH gene

Known as: dihydroorotate dehydrogenase (quinone), Dihydroorotate Dehydrogenase Gene, DHOdehase 
This gene plays a role in pyrimidine metabolism.
National Institutes of Health

Papers overview

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2016
2016
While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic… (More)
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2012
2012
AIM Leflunomide is a disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. Not all patients respond… (More)
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2012
2012
Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo… (More)
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2012
2012
A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently… (More)
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2010
2010
A strategy that combines virtual screening and structure-guided selection of fragments was used to identify three unexplored… (More)
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2010
2010
The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) exhibits anticancer activity in vivo and triggers apoptosis in… (More)
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2009
2009
Pyrimidine biosynthesis is an attractive drug target in a variety of organisms, including humans and the malaria parasite… (More)
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2007
2007
Dihydroorotate dehydrogenase (DHODH; EC 1.3.99.11) is a central enzyme of pyrimidine biosynthesis and catalyzes the oxidation of… (More)
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2004
2004
A novel series of DHODH inhibitors was developed based on a lead which was obtained by a docking procedure and a medicinal… (More)
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1995
1995
The dhod gene encodes dihydroorotate dehydrogenase (DHOdehase), which catalyzes the fourth step of de novo pyrimidine… (More)
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